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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3331
Preferred Name Cyclooxygenase-2
Synonyms COX-2 | COX2 | Cyclooxygenase-2 | PGH synthase 2 | PGHS-2 | PHS II | PTGS2 | Prostaglandin G/H synthase 2 | Prostaglandin H2 synthase 2 | Prostaglandin-endoperoxide synthase 2
Organism Bos taurus
Species Group No
Protein Target Classification
  • enzyme > oxidoreductase

Target Components

Component Description Relationship Accession
Prostaglandin G/H synthase 2 SINGLE PROTEIN O62698

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096674 Cyclooxygenase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0031090 (organelle membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004601 (peroxidase activity)
GO:0004666 (prostaglandin-endoperoxide synthase activity)
GO:0016491 (oxidoreductase activity)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO:0051213 (dioxygenase activity)
GO Biological Process GO:0000212 (meiotic spindle organization)
GO:0001516 (prostaglandin biosynthetic process)
GO:0001550 (ovarian cumulus expansion)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006633 (fatty acid biosynthetic process)
GO:0006693 (prostaglandin metabolic process)
GO:0006954 (inflammatory response)
GO:0006979 (response to oxidative stress)
GO:0008217 (regulation of blood pressure)
GO:0019371 (cyclooxygenase pathway)
GO:0040019 (positive regulation of embryonic development)
GO:0055114 (oxidation-reduction process)
GO:0071347 (cellular response to interleukin-1)
GO:0098869 (cellular oxidant detoxification)
GO:1900195 (positive regulation of oocyte maturation)
GO:1904146 (positive regulation of meiotic cell cycle process involved in oocyte maturation)

Target Cross References - Protein

canSAR O62698
UniProt O46517 O62665 O62698

Target Cross References - Domain

InterPro IPR000742 (EGF-like_dom.)
IPR010255 (Haem_peroxidase.)
IPR019791 (Haem_peroxidase_animal.)
IPR029576 (COX-2.)
IPR037120 (Haem_peroxidase_sf.)
Pfam PF00008 (EGF)
PF03098 (An_peroxidase)