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Target Report Card

Target Name and Classification

Target ID CHEMBL331
Preferred Name Cyclin-dependent kinase 4
Synonyms CDK4 | Cell division protein kinase 4 | Cyclin-dependent kinase 4 | PSK-J3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group

Target Components

Component Description Relationship Accession
Cyclin-dependent kinase 4 SINGLE PROTEIN P11802

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3559691 Cyclin-dependent kinase PROTEIN FAMILY
CHEMBL3885548 Cyclin-A1/Cyclin-dependent kinase 4 PROTEIN COMPLEX
CHEMBL1907601 Cyclin-dependent kinase 4/cyclin D1 PROTEIN COMPLEX
CHEMBL3885553 Cyclin-dependent kinase 4/6 PROTEIN FAMILY
CHEMBL2095942 Cyclin-dependent kinase 4/cyclin D PROTEIN COMPLEX
CHEMBL3885554 Cyclin-dependent kinase 4/G1/S-specific cyclin-E1 PROTEIN COMPLEX
CHEMBL2111326 Cyclin-dependent kinase 2 and 4 (CDK2 and CDK4) SELECTIVITY GROUP
CHEMBL3301385 Cyclin-dependent kinase 4/cyclin D2 PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3301610 ABEMACICLIB Cyclin-dependent kinase 4 inhibitor 4 PubMed
CHEMBL3545110 RIBOCICLIB Cyclin-dependent kinase 4 inhibitor 4 Other PubMed
CHEMBL3707266 RIBOCICLIB SUCCINATE Cyclin-dependent kinase 4 inhibitor 4 Other PubMed
CHEMBL428690 ALVOCIDIB Cyclin-dependent kinase 4 inhibitor 3 PubMed PubMed
CHEMBL384304 RG-547 Cyclin-dependent kinase 4 inhibitor 2
CHEMBL564829 MILCICLIB Cyclin-dependent kinase 4 inhibitor 2 PubMed PubMed
CHEMBL574737 UCN-01 Cyclin-dependent kinase 4 inhibitor 2 Other PubMed PubMed
CHEMBL3545218 VORUCICLIB Cyclin-dependent kinase 4 inhibitor 2 DOI Other Other
CHEMBL3545283 RIVICICLIB Cyclin-dependent kinase 4 inhibitor 2 PubMed PubMed
CHEMBL3544940 G1T28-1 Cyclin-dependent kinase 4 inhibitor 1 DOI DOI Other
CHEMBL3545083 RGB-286638 Cyclin-dependent kinase 4 inhibitor 1 PubMed
CHEMBL3545420 AG-24322 Cyclin-dependent kinase 4 inhibitor 1 Other PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000135446
Ensembl ENSG00000135446
GO Cellular Component GO:0000307 (cyclin-dependent protein kinase holoenzyme complex)
GO:0000785 (chromatin)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005667 (transcription factor complex)
GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005923 (bicellular tight junction)
GO:0016020 (membrane)
GO:0031965 (nuclear membrane)
GO:0032991 (macromolecular complex)
GO:0048471 (perinuclear region of cytoplasm)
GO:0097129 (cyclin D2-CDK4 complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004693 (cyclin-dependent protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016538 (cyclin-dependent protein serine/threonine kinase regulator activity)
GO:0016740 (transferase activity)
GO:0030332 (cyclin binding)
GO:0044877 (macromolecular complex binding)
GO Biological Process GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0002088 (lens development in camera-type eye)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0006468 (protein phosphorylation)
GO:0007049 (cell cycle)
GO:0007165 (signal transduction)
GO:0007275 (multicellular organism development)
GO:0007623 (circadian rhythm)
GO:0008284 (positive regulation of cell proliferation)
GO:0009636 (response to toxic substance)
GO:0010033 (response to organic substance)
GO:0010288 (response to lead ion)
GO:0010468 (regulation of gene expression)
GO:0010971 (positive regulation of G2/M transition of mitotic cell cycle)
GO:0016310 (phosphorylation)
GO:0031100 (organ regeneration)
GO:0031658 (negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle)
GO:0032869 (cellular response to insulin stimulus)
GO:0033574 (response to testosterone)
GO:0040014 (regulation of multicellular organism growth)
GO:0042127 (regulation of cell proliferation)
GO:0042493 (response to drug)
GO:0043065 (positive regulation of apoptotic process)
GO:0045727 (positive regulation of translation)
GO:0045787 (positive regulation of cell cycle)
GO:0045793 (positive regulation of cell size)
GO:0046626 (regulation of insulin receptor signaling pathway)
GO:0046890 (regulation of lipid biosynthetic process)
GO:0048146 (positive regulation of fibroblast proliferation)
GO:0050994 (regulation of lipid catabolic process)
GO:0051301 (cell division)
GO:0051726 (regulation of cell cycle)
GO:0055093 (response to hyperoxia)
GO:0060612 (adipose tissue development)
GO:0071157 (negative regulation of cell cycle arrest)
GO:0071222 (cellular response to lipopolysaccharide)
GO:0071353 (cellular response to interleukin-4)
GO:1904628 (cellular response to phorbol 13-acetate 12-myristate)
GO:1904637 (cellular response to ionomycin)
Wikipedia Cyclin-dependent_kinase_4

Target Cross References - Protein

canSAR P11802
CGD Melanoma, cutaneous malignant, susceptibility to, 3
Human Protein Atlas ENSG00000135446
IntAct P11802
Guide to Pharmacology 1976
Open Targets ENSG00000135446
PharmGKB PA102
Pharos P11802 (Tclin)
Reactome R-HSA-187577 (SCF(Skp2)-mediated degradation of p27/p21.)
R-HSA-2559580 (Oxidative Stress Induced Senescence.)
R-HSA-2559582 (Senescence-Associated Secretory Phenotype (SASP).)
R-HSA-2559585 (Oncogene Induced Senescence.)
R-HSA-3214858 (RMTs methylate histone arginines.)
R-HSA-381340 (Transcriptional regulation of white adipocyte differentiation.)
R-HSA-69229 (Ubiquitin-dependent degradation of Cyclin D1.)
R-HSA-69231 (Cyclin D associated events in G1.)
R-HSA-8849470 (PTK6 Regulates Cell Cycle.)
R-HSA-8878166 (Transcriptional regulation by RUNX2.)
R-HSA-912446 (Meiotic recombination.)
UniProt B2R9A0 B4DNF9 O00576 P11802 Q6FG61

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 2W96 2W99 2W9F 2W9Z 3G33
CREDO 2W96 2W99 2W9F 2W9Z 3G33