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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL330
Target Type SINGLE PROTEIN
Preferred Name Glutamate (NMDA) receptor subunit zeta 1
Synonyms GluN1 | Glutamate [NMDA] receptor subunit zeta-1 | Glutamate receptor ionotropic, NMDA 1 | Grin1 | N-methyl-D-aspartate receptor subunit NR1 | NMD-R1 | Nmdar1
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > ionotropic glutamate receptor > nmda receptor

Target Components

Component Description Relationship Accession
Glutamate receptor ionotropic, NMDA 1 SINGLE PROTEIN P35439

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096911 Glutamate NMDA receptor; Grin1/Grin2c PROTEIN COMPLEX
CHEMBL2096680 Glutamate NMDA receptor; Grin1/Grin2a PROTEIN COMPLEX
CHEMBL2096666 Glutamate NMDA receptor; Grin1/Grin2b PROTEIN COMPLEX
CHEMBL2096669 Glutamate receptors; NMDA/AMPA PROTEIN COMPLEX GROUP
CHEMBL3038506 Ionotropic glutamate receptor NMDA 1/2D PROTEIN COMPLEX
CHEMBL1907608 Glutamate NMDA receptor PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009986 (cell surface)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0017146 (NMDA selective glutamate receptor complex)
GO:0030054 (cell junction)
GO:0032590 (dendrite membrane)
GO:0043025 (neuronal cell body)
GO:0043083 (synaptic cleft)
GO:0043195 (terminal bouton)
GO:0043197 (dendritic spine)
GO:0044307 (dendritic branch)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO:0060076 (excitatory synapse)
GO:0097060 (synaptic membrane)
GO Molecular Function GO:0004970 (ionotropic glutamate receptor activity)
GO:0004972 (NMDA glutamate receptor activity)
GO:0005102 (receptor binding)
GO:0005216 (ion channel activity)
GO:0005234 (extracellular-glutamate-gated ion channel activity)
GO:0005515 (protein binding)
GO:0016594 (glycine binding)
GO:0016595 (glutamate binding)
GO:0019899 (enzyme binding)
GO:0019902 (phosphatase binding)
GO:0022843 (voltage-gated cation channel activity)
GO:0035254 (glutamate receptor binding)
GO:0038023 (signaling receptor activity)
GO:0042165 (neurotransmitter binding)
GO:0044877 (macromolecular complex binding)
GO:0046982 (protein heterodimerization activity)
GO:0046983 (protein dimerization activity)
GO Biological Process GO:0006811 (ion transport)
GO:0007611 (learning or memory)
GO:0010524 (positive regulation of calcium ion transport into cytosol)
GO:0010942 (positive regulation of cell death)
GO:0014070 (response to organic cyclic compound)
GO:0014075 (response to amine)
GO:0034220 (ion transmembrane transport)
GO:0035235 (ionotropic glutamate receptor signaling pathway)
GO:0048511 (rhythmic process)
GO:0051262 (protein tetramerization)
GO:0051290 (protein heterotetramerization)
GO:0051592 (response to calcium ion)
GO:0060079 (excitatory postsynaptic potential)
GO:0060992 (response to fungicide)
GO:0071287 (cellular response to manganese ion)
GO:0098655 (cation transmembrane transport)
GO:1902952 (positive regulation of dendritic spine maintenance)
GO:1903428 (positive regulation of reactive oxygen species biosynthetic process)
GO:2000463 (positive regulation of excitatory postsynaptic potential)
GO:2001056 (positive regulation of cysteine-type endopeptidase activity)

Target Cross References - Protein

canSAR P35439
IntAct P35439
Guide to Pharmacology 455
Reactome R-RNO-3928662 (EPHB-mediated forward signaling.)
R-RNO-438066 (Unblocking of NMDA receptor, glutamate binding and activation.)
R-RNO-442729 (CREB phosphorylation through the activation of CaMKII.)
R-RNO-442982 (Ras activation upon Ca2+ influx through NMDA receptor.)
R-RNO-5673001 (RAF/MAP kinase cascade.)
R-RNO-8849932 (Synaptic adhesion-like molecules.)
UniProt P35439 Q62646

Target Cross References - Domain

InterPro IPR001320 (Iontro_rcpt.)
IPR001508 (Iono_rcpt_met.)
IPR001828 (ANF_lig-bd_rcpt.)
IPR018882 (CaM-bd_C0_NMDA_rcpt_NR1.)
IPR019594 (Glu/Gly-bd.)
IPR028082 (Peripla_BP_I.)
Pfam PF00060 (Lig_chan)
PF01094 (ANF_receptor)
PF10562 (CaM_bdg_C0)
PF10613 (Lig_chan-Glu_bd)

Target Cross References - Structure

PDBe 1PB7 1PB8 1PB9 1PBQ 1Y1M 1Y1Z 1Y20 2A5T 3Q41 4KCC 4KFQ 4NF4 4NF5 4NF6 4NF8 4PE5 5DEX 5I56 5I57 5I58 5I59 5JTY 5U8C 5VIH More...
CREDO 1PB7 1PB8 1PB9 1PBQ 1Y1M 1Y1Z 1Y20 2A5T 3Q41 4KCC 4KFQ 4NF4 4NF5 4NF6 4NF8 4PE5 5DEX 5I56 5I57 5I58 5I59 5JTY 5U8C 5VIH More...
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