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Target Report Card

Target Name and Classification

Target ID CHEMBL3290
Preferred Name Ephrin type-B receptor 2
Synonyms DRT | Developmentally-regulated Eph-related tyrosine kinase | EK5 | ELK-related tyrosine kinase | EPH tyrosine kinase 3 | EPH-like kinase 5 | EPHB2 | EPHT3 | EPTH3 | ERK | Ephrin type-B receptor 2 | HEK5 | Renal carcinoma antigen NY-REN-47 | TYRO5 | Tyrosine-protein kinase TYRO5 | Tyrosine-protein kinase receptor EPH-3 | hEK5
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase eph family

Target Components

Component Description Relationship Accession
Ephrin type-B receptor 2 SINGLE PROTEIN P29323

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363043 Ephrin receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000133216
Ensembl ENSG00000133216
GO Cellular Component GO:0005576 (extracellular region)
GO:0005634 (nucleus)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0042995 (cell projection)
GO:0043025 (neuronal cell body)
GO:0098794 (postsynapse)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0001540 (beta-amyloid binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
GO:0005003 (ephrin receptor activity)
GO:0005005 (transmembrane-ephrin receptor activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008046 (axon guidance receptor activity)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0038023 (signaling receptor activity)
GO:0042802 (identical protein binding)
GO:0044877 (macromolecular complex binding)
GO Biological Process GO:0000902 (cell morphogenesis)
GO:0001525 (angiogenesis)
GO:0001655 (urogenital system development)
GO:0001933 (negative regulation of protein phosphorylation)
GO:0006468 (protein phosphorylation)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007275 (multicellular organism development)
GO:0007399 (nervous system development)
GO:0007411 (axon guidance)
GO:0007413 (axonal fasciculation)
GO:0007611 (learning or memory)
GO:0007612 (learning)
GO:0009887 (organ morphogenesis)
GO:0010628 (positive regulation of gene expression)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0021631 (optic nerve morphogenesis)
GO:0021952 (central nervous system projection neuron axonogenesis)
GO:0022038 (corpus callosum development)
GO:0031290 (retinal ganglion cell axon guidance)
GO:0031915 (positive regulation of synaptic plasticity)
GO:0042472 (inner ear morphogenesis)
GO:0046580 (negative regulation of Ras protein signal transduction)
GO:0048013 (ephrin receptor signaling pathway)
GO:0048168 (regulation of neuronal synaptic plasticity)
GO:0048170 (positive regulation of long-term neuronal synaptic plasticity)
GO:0048593 (camera-type eye morphogenesis)
GO:0050770 (regulation of axonogenesis)
GO:0050771 (negative regulation of axonogenesis)
GO:0050878 (regulation of body fluid levels)
GO:0051389 (inactivation of MAPKK activity)
GO:0051965 (positive regulation of synapse assembly)
GO:0060021 (palate development)
GO:0060996 (dendritic spine development)
GO:0060997 (dendritic spine morphogenesis)
GO:0070373 (negative regulation of ERK1 and ERK2 cascade)
GO:0071679 (commissural neuron axon guidance)
GO:0099557 (trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission)
GO:0106028 (neuron projection retraction)
GO:1900273 (positive regulation of long-term synaptic potentiation)
GO:1903078 (positive regulation of protein localization to plasma membrane)
GO:1904782 (negative regulation of NMDA glutamate receptor activity)
GO:1904783 (positive regulation of NMDA glutamate receptor activity)
Wikipedia EPH_receptor_B2

Target Cross References - Protein

canSAR P29323
Human Protein Atlas ENSG00000133216
IntAct P29323
Guide to Pharmacology 1831
Open Targets ENSG00000133216
PharmGKB PA27825
Pharos P29323 (Tchem)
Reactome R-HSA-2682334 (EPH-Ephrin signaling.)
R-HSA-373760 (L1CAM interactions.)
R-HSA-3928662 (EPHB-mediated forward signaling.)
R-HSA-3928664 (Ephrin signaling.)
R-HSA-3928665 (EPH-ephrin mediated repulsion of cells.)
UniProt O43477 P29323 Q5T0U6 Q5T0U7 Q5T0U8

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001090 (Ephrin_rcpt_lig-bd_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001426 (Tyr_kinase_rcpt_V_CS.)
IPR001660 (SAM.)
IPR003961 (FN3_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR008979 (Galactose-bd-like_sf.)
IPR009030 (Growth_fac_rcpt_cys_sf.)
IPR011009 (Kinase-like_dom_sf.)
IPR011641 (Tyr-kin_ephrin_A/B_rcpt-like.)
IPR013761 (SAM/pointed_sf.)
IPR013783 (Ig-like_fold.)
IPR016257 (Tyr_kinase_ephrin_rcpt.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR027936 (Eph_TM.)
IPR034238 (EphB2_rcpt_lig-bd.)
IPR036116 (FN3_sf.)
Pfam PF00041 (fn3)
PF00536 (SAM_1)
PF01404 (Ephrin_lbd)
PF07699 (Ephrin_rec_like)
PF07714 (Pkinase_Tyr)
PF14575 (EphA2_TM)

Target Cross References - Structure