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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL327
Preferred Name Alpha-2a adrenergic receptor
Synonyms Adra2a | Alpha-2A adrenergic receptor | Alpha-2A adrenoceptor | Alpha-2A adrenoreceptor | Alpha-2AAR | Alpha-2D adrenergic receptor | CA2-47
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > adrenergic receptor

Target Components

Component Description Relationship Accession
Alpha-2A adrenergic receptor SINGLE PROTEIN P22909

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094111 Adrenergic receptor alpha PROTEIN FAMILY
CHEMBL2093864 Adrenergic receptor alpha-2 PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0045202 (synapse)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004935 (adrenergic receptor activity)
GO:0004938 (alpha2-adrenergic receptor activity)
GO Biological Process GO:0002526 (acute inflammatory response)
GO:0006260 (DNA replication)
GO:0006940 (regulation of smooth muscle contraction)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007565 (female pregnancy)
GO:0019229 (regulation of vasoconstriction)
GO:0030168 (platelet activation)
GO:0042593 (glucose homeostasis)
GO:0045955 (negative regulation of calcium ion-dependent exocytosis)
GO:0050955 (thermoception)
GO:0061179 (negative regulation of insulin secretion involved in cellular response to glucose stimulus)
GO:0070473 (negative regulation of uterine smooth muscle contraction)
GO:0071880 (adenylate cyclase-activating adrenergic receptor signaling pathway)
GO:0097755 (positive regulation of blood vessel diameter)

Target Cross References - Protein

canSAR P22909
UniProt P22909

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR001946 (ADRA2A_rcpt.)
IPR002233 (ADR_fam.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)