ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL326
Preferred Name Alpha-1d adrenergic receptor
Synonyms Adra1a | Adra1d | Alpha-1A adrenergic receptor | Alpha-1D adrenergic receptor | Alpha-1D adrenoceptor | Alpha-1D adrenoreceptor | RA42
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > adrenergic receptor

Target Components

Component Description Relationship Accession
Alpha-1D adrenergic receptor SINGLE PROTEIN P23944

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL1907610 Adrenergic receptor alpha-1 PROTEIN FAMILY
CHEMBL2097171 Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 SELECTIVITY GROUP
CHEMBL2094111 Adrenergic receptor alpha PROTEIN FAMILY
CHEMBL2111447 Alpha adrenergic receptor 1A and 1D SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004935 (adrenergic receptor activity)
GO:0004937 (alpha1-adrenergic receptor activity)
GO Biological Process GO:0001994 (norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007267 (cell-cell signaling)
GO:0007568 (aging)
GO:0045907 (positive regulation of vasoconstriction)
GO:0045987 (positive regulation of smooth muscle contraction)
GO:0060073 (micturition)
GO:0071880 (adenylate cyclase-activating adrenergic receptor signaling pathway)

Target Cross References - Protein

canSAR P23944
Guide to Pharmacology 24
UniProt P23944 Q71UM4

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000363 (ADRA1D_rcpt.)
IPR002233 (ADR_fam.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)