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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3259
Target Type SINGLE PROTEIN
Preferred Name Aminopeptidase N
Synonyms AP-M | AP-N | Alanyl aminopeptidase | Aminopeptidase M | Aminopeptidase N | Anpep | CD_antigen=CD13 | KZP | Kidney Zn peptidase | Microsomal aminopeptidase | rAPN
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mae clan > metallo protease m1 family

Target Components

Component Description Relationship Accession
Aminopeptidase N SINGLE PROTEIN P15684

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0012506 (vesicle membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031983 (vesicle lumen)
GO Molecular Function GO:0004177 (aminopeptidase activity)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0042277 (peptide binding)
GO:0046872 (metal ion binding)
GO:0070006 (metalloaminopeptidase activity)
GO Biological Process GO:0001525 (angiogenesis)
GO:0006508 (proteolysis)
GO:0006725 (cellular aromatic compound metabolic process)
GO:0007275 (multicellular organism development)
GO:0030154 (cell differentiation)
GO:0035814 (negative regulation of renal sodium excretion)
GO:0043171 (peptide catabolic process)

Target Cross References - Protein

canSAR P15684
IntAct P15684
MICAD NBK23141 (Aminopeptidase N (CD13))
NBK23309 (Aminopeptidase N (CD13))
NBK23453 (Aminopeptidase N (CD13))
UniProt P15684 Q9JHP4

Target Cross References - Domain

InterPro IPR001930 (Peptidase_M1.)
IPR014782 (Peptidase_M1_N.)
IPR024571 (ERAP1-like_C_dom.)
IPR034016 (M1_APN-typ.)
Pfam PF01433 (Peptidase_M1)
PF11838 (ERAP1_C)
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