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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3254
Target Type SINGLE PROTEIN
Preferred Name Monoamine oxidase A
Synonyms Amine oxidase [flavin-containing] A | MAO-A | MAOA | Monoamine oxidase type A
Organism Bos taurus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Amine oxidase [flavin-containing] A SINGLE PROTEIN P21398

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111399 Monoamine oxidase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005739 (mitochondrion)
GO:0005741 (mitochondrial outer membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0008131 (primary amine oxidase activity)
GO:0016491 (oxidoreductase activity)
GO Biological Process GO:0006584 (catecholamine metabolic process)
GO:0042135 (neurotransmitter catabolic process)
GO:0042420 (dopamine catabolic process)
GO:0055114 (oxidation-reduction process)

Target Cross References - Protein

canSAR P21398
Reactome R-BTA-141333 (Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB.)
R-BTA-181430 (Norepinephrine Neurotransmitter Release Cycle.)
R-BTA-379397 (Enzymatic degradation of dopamine by COMT.)
R-BTA-379398 (Enzymatic degradation of Dopamine by monoamine oxidase.)
R-BTA-380612 (Metabolism of serotonin.)
UniProt P21398 Q0IIE7

Target Cross References - Domain

InterPro IPR001613 (Flavin_amine_oxidase.)
IPR002937 (Amino_oxidase.)
IPR023753 (FAD/NAD-binding_dom.)
Pfam PF01593 (Amino_oxidase)
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