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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3252
Target Type SINGLE PROTEIN
Preferred Name Beta-1 adrenergic receptor
Synonyms Adrb1 | Adrb1r | Beta-1 adrenergic receptor | Beta-1 adrenoceptor | Beta-1 adrenoreceptor
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > adrenergic receptor

Target Components

Component Description Relationship Accession
Beta-1 adrenergic receptor SINGLE PROTEIN P18090

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095166 Adrenergic receptor beta PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005768 (endosome)
GO:0005769 (early endosome)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0098794 (postsynapse)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004935 (adrenergic receptor activity)
GO:0004940 (beta1-adrenergic receptor activity)
GO:0005057 (receptor signaling protein activity)
GO:0005088 (Ras guanyl-nucleotide exchange factor activity)
GO:0005515 (protein binding)
GO:0008144 (drug binding)
GO:0035240 (dopamine binding)
GO:0051379 (epinephrine binding)
GO:0051380 (norepinephrine binding)
GO Biological Process GO:0001659 (temperature homeostasis)
GO:0001996 (positive regulation of heart rate by epinephrine-norepinephrine)
GO:0002025 (vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure)
GO:0003061 (positive regulation of the force of heart contraction by norepinephrine)
GO:0003084 (positive regulation of systemic arterial blood pressure)
GO:0005980 (glycogen catabolic process)
GO:0006915 (apoptotic process)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007266 (Rho protein signal transduction)
GO:0007568 (aging)
GO:0007613 (memory)
GO:0010460 (positive regulation of heart rate)
GO:0019233 (sensory perception of pain)
GO:0030819 (positive regulation of cAMP biosynthetic process)
GO:0033365 (protein localization to organelle)
GO:0035811 (negative regulation of urine volume)
GO:0042060 (wound healing)
GO:0043065 (positive regulation of apoptotic process)
GO:0043547 (positive regulation of GTPase activity)
GO:0043950 (positive regulation of cAMP-mediated signaling)
GO:0045762 (positive regulation of adenylate cyclase activity)
GO:0045823 (positive regulation of heart contraction)
GO:0045986 (negative regulation of smooth muscle contraction)
GO:0046878 (positive regulation of saliva secretion)
GO:0051924 (regulation of calcium ion transport)
GO:0055088 (lipid homeostasis)
GO:0060080 (inhibitory postsynaptic potential)
GO:0061051 (positive regulation of cell growth involved in cardiac muscle cell development)
GO:0071880 (adenylate cyclase-activating adrenergic receptor signaling pathway)
GO:0086004 (regulation of cardiac muscle cell contraction)
GO:1900135 (positive regulation of renin secretion into blood stream)
GO:1900273 (positive regulation of long-term synaptic potentiation)
GO:2001259 (positive regulation of cation channel activity)

Target Cross References - Protein

canSAR P18090
IntAct P18090
UniProt P18090

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000507 (ADRB1_rcpt.)
IPR002233 (ADR_fam.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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