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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL324
Target Type SINGLE PROTEIN
Preferred Name Serotonin 2c (5-HT2c) receptor
Synonyms 5-HT-1C | 5-HT-2C | 5-HT1C | 5-HT2C | 5-HTR2C | 5-hydroxytryptamine receptor 1C | 5-hydroxytryptamine receptor 2C | 5ht1c | Htr1c | Htr2c | Serotonin receptor 2C
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > serotonin receptor

Target Components

Component Description Relationship Accession
5-hydroxytryptamine receptor 2C SINGLE PROTEIN P08909

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094123 Serotonin (5-HT) receptor PROTEIN FAMILY
CHEMBL2111383 Serotonin receptor 2a and 2c (5HT2A and 5HT2C) SELECTIVITY GROUP
CHEMBL2097175 Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor SELECTIVITY GROUP
CHEMBL2093870 Serotonin 2 (5-HT2) receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0001587 (Gq/11-coupled serotonin receptor activity)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004993 (G-protein coupled serotonin receptor activity)
GO:0005515 (protein binding)
GO:0030594 (neurotransmitter receptor activity)
GO Biological Process GO:0001662 (behavioral fear response)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007187 (G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)
GO:0007208 (phospholipase C-activating serotonin receptor signaling pathway)
GO:0007610 (behavior)
GO:0007626 (locomotory behavior)
GO:0007631 (feeding behavior)
GO:0014054 (positive regulation of gamma-aminobutyric acid secretion)
GO:0014057 (positive regulation of acetylcholine secretion, neurotransmission)
GO:0031100 (organ regeneration)
GO:0031583 (phospholipase D-activating G-protein coupled receptor signaling pathway)
GO:0031644 (regulation of neurological system process)
GO:0032098 (regulation of appetite)
GO:0035095 (behavioral response to nicotine)
GO:0040013 (negative regulation of locomotion)
GO:0042493 (response to drug)
GO:0043397 (regulation of corticotropin-releasing hormone secretion)
GO:0045907 (positive regulation of vasoconstriction)
GO:0045963 (negative regulation of dopamine metabolic process)
GO:0048016 (inositol phosphate-mediated signaling)
GO:0051209 (release of sequestered calcium ion into cytosol)
GO:0051482 (positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway)
GO:0051930 (regulation of sensory perception of pain)

Target Cross References - Protein

canSAR P08909
Guide to Pharmacology 8
UniProt P08909

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000377 (5HT2C_rcpt.)
IPR002231 (5HT_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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