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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3229
Target Type SINGLE PROTEIN
Preferred Name Anandamide amidohydrolase
Synonyms Anandamide amidohydrolase 1 | Faah | Faah1 | Fatty-acid amide hydrolase 1 | Oleamide hydrolase 1
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Fatty-acid amide hydrolase 1 SINGLE PROTEIN P97612

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0000139 (Golgi membrane)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005794 (Golgi apparatus)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031090 (organelle membrane)
GO Molecular Function GO:0004040 (amidase activity)
GO:0005515 (protein binding)
GO:0005543 (phospholipid binding)
GO:0008289 (lipid binding)
GO:0016787 (hydrolase activity)
GO:0016788 (hydrolase activity, acting on ester bonds)
GO:0017064 (fatty acid amide hydrolase activity)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0102077 (oleamide hydrolase activity)
GO:0103073 (anandamide amidohydrolase activity)
GO Biological Process GO:0006631 (fatty acid metabolic process)
GO:0009062 (fatty acid catabolic process)
GO:0097756 (negative regulation of blood vessel diameter)

Target Cross References - Protein

canSAR P97612
Guide to Pharmacology 1400
Reactome R-RNO-2142753 (Arachidonic acid metabolism.)
UniProt P97612 Q5BKA3

Target Cross References - Domain

InterPro IPR000120 (Amidase.)
IPR020556 (Amidase_CS.)
IPR023631 (Amidase_dom.)
IPR030560 (FAAH.)
IPR036928 (AS_sf.)
Pfam PF01425 (Amidase)

Target Cross References - Structure

PDBe 1MT5 2VYA 2WAP 2WJ1 2WJ2 3K7F 3K83 3K84 3LJ6 3LJ7 3OJ8 3PPM 3PR0 3QJ8 3QJ9 3QK5 3QKV 4DO3 4HBP 4J5P
CREDO 1MT5 2VYA 2WAP 2WJ1 2WJ2 3K7F 3K83 3K84 3LJ6 3LJ7 3OJ8 3PPM 3PR0 3QJ8 3QJ9 3QK5 3QKV 4DO3 4HBP 4J5P
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