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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3223
Target Type SINGLE PROTEIN
Preferred Name Serotonin 7 (5-HT7) receptor
Synonyms 5-HT-7 | 5-HT-X | 5-HT7 | 5-hydroxytryptamine receptor 7 | GPRFO | Htr7 | Serotonin receptor 7
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > serotonin receptor

Target Components

Component Description Relationship Accession
5-hydroxytryptamine receptor 7 SINGLE PROTEIN P32305

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094123 Serotonin (5-HT) receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005791 (rough endoplasmic reticulum)
GO:0005886 (plasma membrane)
GO:0008021 (synaptic vesicle)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030425 (dendrite)
GO:0043025 (neuronal cell body)
GO:0043679 (axon terminus)
GO:0098794 (postsynapse)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004993 (G-protein coupled serotonin receptor activity)
GO:0030594 (neurotransmitter receptor activity)
GO Biological Process GO:0006939 (smooth muscle contraction)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007187 (G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)
GO:0007192 (adenylate cyclase-activating serotonin receptor signaling pathway)
GO:0007210 (serotonin receptor signaling pathway)
GO:0007268 (chemical synaptic transmission)
GO:0007613 (memory)
GO:0007623 (circadian rhythm)
GO:0010976 (positive regulation of neuron projection development)
GO:0014063 (negative regulation of serotonin secretion)
GO:0014832 (urinary bladder smooth muscle contraction)
GO:0042310 (vasoconstriction)
GO:0042322 (negative regulation of circadian sleep/wake cycle, REM sleep)
GO:0048266 (behavioral response to pain)
GO:0050966 (detection of mechanical stimulus involved in sensory perception of pain)
GO:0051412 (response to corticosterone)
GO:0051602 (response to electrical stimulus)
GO:0060073 (micturition)
GO:0060291 (long-term synaptic potentiation)
GO:0071542 (dopaminergic neuron differentiation)
GO:0099565 (chemical synaptic transmission, postsynaptic)

Target Cross References - Protein

canSAR P32305
Guide to Pharmacology 12
Reactome R-RNO-390666 (Serotonin receptors.)
R-RNO-418555 (G alpha (s) signalling events.)
UniProt P32305 P97936

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR001069 (5HT_7_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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