ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL3222
Target Type SINGLE PROTEIN
Preferred Name Delta opioid receptor
Synonyms D-OR-1 | DOR-1 | Delta-type opioid receptor | K56 | MSL-2 | Oprd1
Organism Mus musculus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > opioid receptor

Target Components

Component Description Relationship Accession
Delta-type opioid receptor SINGLE PROTEIN P32300

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2221343 Opioid receptors; mu and delta PROTEIN FAMILY
CHEMBL2095192 Opioid receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030285 (integral component of synaptic vesicle membrane)
GO:0031226 (intrinsic component of plasma membrane)
GO:0031982 (vesicle)
GO:0032590 (dendrite membrane)
GO:0043679 (axon terminus)
GO:0045121 (membrane raft)
GO:0045211 (postsynaptic membrane)
GO:0097444 (spine apparatus)
GO:0098992 (neuronal dense core vesicle)
GO:0099056 (integral component of presynaptic membrane)
GO:0099061 (integral component of postsynaptic density membrane)
GO Molecular Function GO:0004930 (G protein-coupled receptor activity)
GO:0004985 (opioid receptor activity)
GO:0005515 (protein binding)
GO:0033612 (receptor serine/threonine kinase binding)
GO:0038046 (enkephalin receptor activity)
GO:0042277 (peptide binding)
GO:0042923 (neuropeptide binding)
GO Biological Process GO:0000060 (protein import into nucleus, translocation)
GO:0007165 (signal transduction)
GO:0007191 (adenylate cyclase-activating dopamine receptor signaling pathway)
GO:0008344 (adult locomotory behavior)
GO:0010629 (negative regulation of gene expression)
GO:0032460 (negative regulation of protein oligomerization)
GO:0033138 (positive regulation of peptidyl-serine phosphorylation)
GO:0042755 (eating behavior)
GO:0051881 (regulation of mitochondrial membrane potential)
GO:0051924 (regulation of calcium ion transport)
GO:0051930 (regulation of sensory perception of pain)
GO:0071363 (cellular response to growth factor stimulus)
GO:0071456 (cellular response to hypoxia)
GO:0097237 (cellular response to toxic substance)

Target Cross References - Protein

canSAR P32300
IntAct P32300
Guide to Pharmacology 317
MICAD NBK23011 (Delta opioid receptor)
Reactome R-MMU-375276 (Peptide ligand-binding receptors.)
R-MMU-418594 (G alpha (i) signalling events.)
UniProt P32300

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000321 (Delta_opi_rcpt.)
IPR001418 (Opioid_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)

Target Cross References - Structure

PDBe 4EJ4
CREDO 4EJ4
spacer
spacer