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Target Report Card

Target Name and Classification

Target ID CHEMBL3214
Target Type SINGLE PROTEIN
Preferred Name Beta-1,4-galactosyltransferase 1
Synonyms B4GALT1 | Beta-1,4-GalTase 1 | Beta-1,4-galactosyltransferase 1 | Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase | Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase | Beta4Gal-T1 | GALT | GGTB2 | Lactose synthase A protein | N-acetyllactosamine synthase | Nal synthase | Processed beta-1,4-galactosyltransferase 1 | UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1 | UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1 | b4Gal-T1
Organism Bos taurus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Beta-1,4-galactosyltransferase 1 SINGLE PROTEIN P08037

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0000138 (Golgi trans cisterna)
GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO:0030057 (desmosome)
GO:0030112 (glycocalyx)
GO:0030175 (filopodium)
GO:0031526 (brush border membrane)
GO:0032580 (Golgi cisterna membrane)
GO:0042995 (cell projection)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0003831 (beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity)
GO:0003945 (N-acetyllactosamine synthase activity)
GO:0004461 (lactose synthase activity)
GO:0005515 (protein binding)
GO:0008092 (cytoskeletal protein binding)
GO:0008378 (galactosyltransferase activity)
GO:0016740 (transferase activity)
GO:0016757 (transferase activity, transferring glycosyl groups)
GO:0030145 (manganese ion binding)
GO:0035250 (UDP-galactosyltransferase activity)
GO:0042803 (protein homodimerization activity)
GO:0043014 (alpha-tubulin binding)
GO:0046872 (metal ion binding)
GO:0048487 (beta-tubulin binding)
GO Biological Process GO:0002064 (epithelial cell development)
GO:0002526 (acute inflammatory response)
GO:0005975 (carbohydrate metabolic process)
GO:0005989 (lactose biosynthetic process)
GO:0006012 (galactose metabolic process)
GO:0006486 (protein glycosylation)
GO:0006487 (protein N-linked glycosylation)
GO:0007155 (cell adhesion)
GO:0007339 (binding of sperm to zona pellucida)
GO:0007341 (penetration of zona pellucida)
GO:0008285 (negative regulation of cell proliferation)
GO:0009101 (glycoprotein biosynthetic process)
GO:0009312 (oligosaccharide biosynthetic process)
GO:0030198 (extracellular matrix organization)
GO:0030879 (mammary gland development)
GO:0042060 (wound healing)
GO:0042127 (regulation of cell proliferation)
GO:0043065 (positive regulation of apoptotic process)
GO:0045136 (development of secondary sexual characteristics)
GO:0048754 (branching morphogenesis of an epithelial tube)
GO:0050900 (leukocyte migration)
GO:0051270 (regulation of cellular component movement)
GO:0060046 (regulation of acrosome reaction)
GO:0060054 (positive regulation of epithelial cell proliferation involved in wound healing)
GO:0060055 (angiogenesis involved in wound healing)
GO:0060058 (positive regulation of apoptotic process involved in mammary gland involution)

Target Cross References - Protein

canSAR P08037
IntAct P08037
Reactome R-BTA-1300644 (Interaction With The Zona Pellucida.)
R-BTA-2022854 (Keratan sulfate biosynthesis.)
R-BTA-5653890 (Lactose synthesis.)
R-BTA-6798695 (Neutrophil degranulation.)
R-BTA-975577 (N-Glycan antennae elongation.)
UniProt P08037 Q0VC05 Q8MIG0

Target Cross References - Domain

InterPro IPR003859 (Galactosyl_T.)
IPR027791 (Galactosyl_T_C.)
IPR027995 (Galactosyl_T_N.)
IPR029044 (Nucleotide-diphossugar_trans.)
Pfam PF02709 (Glyco_transf_7C)
PF13733 (Glyco_transf_7N)

Target Cross References - Structure

PDBe 1FGX 1FR8 1NF5 1NHE 1NKH 1NMM 1NQI 1NWG 1O0R 1O23 1OQM 1PZT 1PZY 1TVY 1TW1 1TW5 1YRO 2FYC 2FYD 4KRV
CREDO 1FGX 1FR8 1NF5 1NHE 1NKH 1NMM 1NQI 1NWG 1O0R 1O23 1OQM 1PZT 1PZY 1TVY 1TW1 1TW5 1YRO 2FYC 2FYD 4KRV
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