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Target Report Card

Target Name and Classification

Target ID CHEMBL321
Preferred Name Matrix metalloproteinase 9
Synonyms 67 kDa matrix metalloproteinase-9 | 82 kDa matrix metalloproteinase-9 | 92 kDa gelatinase | 92 kDa type IV collagenase | CLG4B | GELB | Gelatinase B | MMP-9 | MMP9 | Matrix metalloproteinase-9
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mam clan > metallo protease m10a subfamily

Target Components

Component Description Relationship Accession
Matrix metalloproteinase-9 SINGLE PROTEIN P14780

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3885505 Matrix metalloproteinase 2/9 PROTEIN FAMILY
CHEMBL2095216 Collagenase PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL279785 MARIMASTAT Matrix metalloproteinase 9 inhibitor 3 PubMed PubMed PubMed
CHEMBL3833374 ANDECALIXIMAB Matrix metalloproteinase 9 inhibitor 3 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000100985
Ensembl ENSG00000100985
GO Cellular Component GO:0005576 (extracellular region)
GO:0005578 (proteinaceous extracellular matrix)
GO:0005615 (extracellular space)
GO:0031012 (extracellular matrix)
GO:0070062 (extracellular exosome)
GO:1904724 (tertiary granule lumen)
GO:1904813 (ficolin-1-rich granule lumen)
GO Molecular Function GO:0004175 (endopeptidase activity)
GO:0004222 (metalloendopeptidase activity)
GO:0004252 (serine-type endopeptidase activity)
GO:0005515 (protein binding)
GO:0005518 (collagen binding)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0042802 (identical protein binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001501 (skeletal system development)
GO:0001503 (ossification)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0006508 (proteolysis)
GO:0007566 (embryo implantation)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0022617 (extracellular matrix disassembly)
GO:0030198 (extracellular matrix organization)
GO:0030225 (macrophage differentiation)
GO:0030335 (positive regulation of cell migration)
GO:0030574 (collagen catabolic process)
GO:0034614 (cellular response to reactive oxygen species)
GO:0035987 (endodermal cell differentiation)
GO:0043065 (positive regulation of apoptotic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0043312 (neutrophil degranulation)
GO:0043388 (positive regulation of DNA binding)
GO:0045742 (positive regulation of epidermal growth factor receptor signaling pathway)
GO:0048013 (ephrin receptor signaling pathway)
GO:0050900 (leukocyte migration)
GO:0051549 (positive regulation of keratinocyte migration)
GO:0071276 (cellular response to cadmium ion)
GO:0090200 (positive regulation of release of cytochrome c from mitochondria)
GO:1900122 (positive regulation of receptor binding)
GO:1904707 (positive regulation of vascular smooth muscle cell proliferation)
GO:2001243 (negative regulation of intrinsic apoptotic signaling pathway)
GO:2001258 (negative regulation of cation channel activity)
GO:2001268 (negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)
Wikipedia MMP9

Target Cross References - Protein

canSAR P14780
CGD Metaphyseal anadysplasia 2
Human Protein Atlas ENSG00000100985
IntAct P14780
Guide to Pharmacology 1633
Open Targets ENSG00000100985
PharmGKB PA30889
Reactome R-HSA-1433557 (Signaling by SCF-KIT.)
R-HSA-1442490 (Collagen degradation.)
R-HSA-1474228 (Degradation of the extracellular matrix.)
R-HSA-1592389 (Activation of Matrix Metalloproteinases.)
R-HSA-2022090 (Assembly of collagen fibrils and other multimeric structures.)
R-HSA-3928665 (EPH-ephrin mediated repulsion of cells.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
R-HSA-6798695 (Neutrophil degranulation.)
UniProt B2R7V9 P14780 Q3LR70 Q8N725 Q9H4Z1 Q9UCJ9 Q9UCL1 Q9UDK2

Target Cross References - Domain

InterPro IPR000562 (FN_type2_dom.)
IPR000585 (Hemopexin-like_dom.)
IPR001818 (Pept_M10_metallopeptidase.)
IPR002477 (Peptidoglycan-bd-like.)
IPR006026 (Peptidase_Metallo.)
IPR013806 (Kringle-like.)
IPR018486 (Hemopexin_CS.)
IPR018487 (Hemopexin-like_repeat.)
IPR021158 (Pept_M10A_Zn_BS.)
IPR021190 (Pept_M10A.)
IPR024079 (MetalloPept_cat_dom_sf.)
IPR028688 (MMP9.)
IPR033739 (M10A_MMP.)
IPR036365 (PGBD-like_sf.)
IPR036366 (PGBDSf.)
IPR036375 (Hemopexin-like_dom_sf.)
IPR036943 (FN_type2_sf.)
Pfam PF00040 (fn2)
PF00045 (Hemopexin)
PF00413 (Peptidase_M10)
PF01471 (PG_binding_1)

Target Cross References - Structure

PDBe 1GKC 1GKD 1ITV 1L6J 2OVX 2OVZ 2OW0 2OW1 2OW2 4H1Q 4H2E 4H3X 4H82 4HMA 4JIJ 4JQG 4WZV 4XCT 5CUH 5I12 5TH6 5TH9 5UE3 5UE4
CREDO 1GKC 1GKD 1ITV 1L6J 2OVX 2OVZ 2OW0 2OW1 2OW2 4H1Q 4H2E 4H3X 4H82 4HMA 4JIJ 4JQG 4WZV 4XCT 5CUH 5I12 5TH6 5TH9 5UE3 5UE4