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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3206
Target Type SINGLE PROTEIN
Preferred Name Adenosine deaminase
Synonyms Ada | Adenosine aminohydrolase | Adenosine deaminase
Organism Mus musculus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Adenosine deaminase SINGLE PROTEIN P03958

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005615 (extracellular space)
GO:0005737 (cytoplasm)
GO:0005764 (lysosome)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0030054 (cell junction)
GO:0031410 (cytoplasmic vesicle)
GO:0032839 (dendrite cytoplasm)
GO:0043025 (neuronal cell body)
GO:0060205 (cytoplasmic membrane-bounded vesicle lumen)
GO Molecular Function GO:0001883 (purine nucleoside binding)
GO:0004000 (adenosine deaminase activity)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0019239 (deaminase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0001701 (in utero embryonic development)
GO:0001821 (histamine secretion)
GO:0001829 (trophectodermal cell differentiation)
GO:0001889 (liver development)
GO:0001890 (placenta development)
GO:0002314 (germinal center B cell differentiation)
GO:0002636 (positive regulation of germinal center formation)
GO:0002686 (negative regulation of leukocyte migration)
GO:0002906 (negative regulation of mature B cell apoptotic process)
GO:0006154 (adenosine catabolic process)
GO:0006157 (deoxyadenosine catabolic process)
GO:0007155 (cell adhesion)
GO:0007568 (aging)
GO:0009117 (nucleotide metabolic process)
GO:0009168 (purine ribonucleoside monophosphate biosynthetic process)
GO:0010460 (positive regulation of heart rate)
GO:0030324 (lung development)
GO:0030890 (positive regulation of B cell proliferation)
GO:0032261 (purine nucleotide salvage)
GO:0033089 (positive regulation of T cell differentiation in thymus)
GO:0033197 (response to vitamin E)
GO:0033632 (regulation of cell-cell adhesion mediated by integrin)
GO:0042110 (T cell activation)
GO:0042323 (negative regulation of circadian sleep/wake cycle, non-REM sleep)
GO:0042493 (response to drug)
GO:0042542 (response to hydrogen peroxide)
GO:0043066 (negative regulation of apoptotic process)
GO:0043103 (hypoxanthine salvage)
GO:0043278 (response to morphine)
GO:0045187 (regulation of circadian sleep/wake cycle, sleep)
GO:0045580 (regulation of T cell differentiation)
GO:0045582 (positive regulation of T cell differentiation)
GO:0045987 (positive regulation of smooth muscle contraction)
GO:0046061 (dATP catabolic process)
GO:0046085 (adenosine metabolic process)
GO:0046101 (hypoxanthine biosynthetic process)
GO:0046103 (inosine biosynthetic process)
GO:0046111 (xanthine biosynthetic process)
GO:0046638 (positive regulation of alpha-beta T cell differentiation)
GO:0048286 (lung alveolus development)
GO:0048541 (Peyer's patch development)
GO:0048566 (embryonic digestive tract development)
GO:0050728 (negative regulation of inflammatory response)
GO:0050850 (positive regulation of calcium-mediated signaling)
GO:0050862 (positive regulation of T cell receptor signaling pathway)
GO:0050870 (positive regulation of T cell activation)
GO:0060169 (negative regulation of adenosine receptor signaling pathway)
GO:0060407 (negative regulation of penile erection)
GO:0070244 (negative regulation of thymocyte apoptotic process)
GO:0070256 (negative regulation of mucus secretion)

Target Cross References - Protein

canSAR P03958
IntAct P03958
Reactome R-MMU-74217 (Purine salvage.)
UniProt P03958

Target Cross References - Domain

InterPro IPR001365 (A/AMP_deaminase_dom.)
IPR006330 (Ado/ade_deaminase.)
IPR006650 (A/AMP_deam_AS.)
IPR028893 (A_deaminase.)
IPR032466 (Metal_Hydrolase.)
Pfam PF00962 (A_deaminase)

Target Cross References - Structure

PDBe 1A4L 1A4M 1ADD 1FKW 1FKX 1UIO 1UIP 2ADA 3KM8 3MVI 3MVT 3T1G
CREDO 1A4L 1A4M 1ADD 1FKW 1FKX 1UIO 1UIP 2ADA 3KM8 3MVI 3MVT 3T1G
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