ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL320
Preferred Name Muscarinic acetylcholine receptor M3
Synonyms Chrm-3 | Chrm3 | Muscarinic acetylcholine receptor M3
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > acetylcholine receptor

Target Components

Component Description Relationship Accession
Muscarinic acetylcholine receptor M3 SINGLE PROTEIN P08483

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111347 Muscarinic receptor M2 and M3 SELECTIVITY GROUP
CHEMBL1907609 Muscarinic acetylcholine receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO:0030054 (cell junction)
GO:0030425 (dendrite)
GO:0032279 (asymmetric synapse)
GO:0043679 (axon terminus)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0005515 (protein binding)
GO:0008144 (drug binding)
GO:0016907 (G-protein coupled acetylcholine receptor activity)
GO:0042166 (acetylcholine binding)
GO Biological Process GO:0003056 (regulation of vascular smooth muscle contraction)
GO:0006939 (smooth muscle contraction)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007197 (adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway)
GO:0007207 (phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway)
GO:0007213 (G-protein coupled acetylcholine receptor signaling pathway)
GO:0007271 (synaptic transmission, cholinergic)
GO:0019229 (regulation of vasoconstriction)
GO:0045987 (positive regulation of smooth muscle contraction)
GO:0046541 (saliva secretion)

Target Cross References - Protein

canSAR P08483
IntAct P08483
Guide to Pharmacology 15
Reactome R-RNO-390648 (Muscarinic acetylcholine receptors.)
R-RNO-416476 (G alpha (q) signalling events.)
UniProt P08483 Q9QWK9

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000995 (Musac_Ach_rcpt.)
IPR001183 (Musac_Ach_M3_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)

Target Cross References - Structure

PDBe 4DAJ 4U14 4U15 4U16
CREDO 4DAJ 4U14 4U15 4U16