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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3199
Preferred Name Acetylcholinesterase
Synonyms AChE | Acetylcholinesterase | Ache
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme > hydrolase

Target Components

Component Description Relationship Accession
Acetylcholinesterase SINGLE PROTEIN P37136

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111475 Acetylcholinesterase and butyrylcholinesterase (AChE and BChE) SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005576 (extracellular region)
GO:0005635 (nuclear envelope)
GO:0005737 (cytoplasm)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005791 (rough endoplasmic reticulum)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0030054 (cell junction)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0031225 (anchored component of membrane)
GO:0042734 (presynaptic membrane)
GO:0043005 (neuron projection)
GO:0043025 (neuronal cell body)
GO:0043083 (synaptic cleft)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0003990 (acetylcholinesterase activity)
GO:0004104 (cholinesterase activity)
GO:0016787 (hydrolase activity)
GO:0033265 (choline binding)
GO:0042166 (acetylcholine binding)
GO:0052689 (carboxylic ester hydrolase activity)
GO Biological Process GO:0001507 (acetylcholine catabolic process in synaptic cleft)
GO:0006581 (acetylcholine catabolic process)
GO:0007416 (synapse assembly)
GO:0008291 (acetylcholine metabolic process)
GO:0019695 (choline metabolic process)
GO:0042135 (neurotransmitter catabolic process)
GO:0050772 (positive regulation of axonogenesis)
GO:0050775 (positive regulation of dendrite morphogenesis)
GO:0070997 (neuron death)

Target Cross References - Protein

canSAR P37136
MICAD NBK23068 (Acetylcholinesterase (AChE))
NBK23350 (Acetylcholinerase (AChE))
NBK23629 (Acetylcholinesterase (AChE))
NBK47023 (Acetylcholinesterase (AChE))
UniProt P37136

Target Cross References - Domain

InterPro IPR000997 (Cholinesterase.)
IPR002018 (CarbesteraseB.)
IPR014788 (AChE_tetra.)
IPR019819 (Carboxylesterase_B_CS.)
IPR019826 (Carboxylesterase_B_AS.)
IPR029058 (AB_hydrolase.)
Pfam PF00135 (COesterase)
PF08674 (AChE_tetra)