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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3198
Target Type SINGLE PROTEIN
Preferred Name Acetylcholinesterase
Synonyms AChE | Acetylcholinesterase | Ache
Organism Mus musculus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Acetylcholinesterase SINGLE PROTEIN P21836

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005576 (extracellular region)
GO:0005605 (basal lamina)
GO:0005615 (extracellular space)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0030054 (cell junction)
GO:0031225 (anchored component of membrane)
GO:0031594 (neuromuscular junction)
GO:0045202 (synapse)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0003990 (acetylcholinesterase activity)
GO:0004104 (cholinesterase activity)
GO:0005515 (protein binding)
GO:0005518 (collagen binding)
GO:0016787 (hydrolase activity)
GO:0017171 (serine hydrolase activity)
GO:0042166 (acetylcholine binding)
GO:0042803 (protein homodimerization activity)
GO:0043236 (laminin binding)
GO:0043621 (protein self-association)
GO:0052689 (carboxylic ester hydrolase activity)
GO Biological Process GO:0001919 (regulation of receptor recycling)
GO:0002076 (osteoblast development)
GO:0006581 (acetylcholine catabolic process)
GO:0007155 (cell adhesion)
GO:0031623 (receptor internalization)
GO:0042135 (neurotransmitter catabolic process)
GO:0045212 (neurotransmitter receptor biosynthetic process)
GO:0051262 (protein tetramerization)
GO:0060041 (retina development in camera-type eye)

Target Cross References - Protein

canSAR P21836
IntAct P21836
MICAD NBK23068 (Acetylcholinesterase (AChE))
NBK23350 (Acetylcholinerase (AChE))
NBK23629 (Acetylcholinesterase (AChE))
NBK47023 (Acetylcholinesterase (AChE))
Reactome R-MMU-112311 (Neurotransmitter Clearance In The Synaptic Cleft.)
R-MMU-1483191 (Synthesis of PC.)
UniProt P21836

Target Cross References - Domain

InterPro IPR000997 (Cholinesterase.)
IPR002018 (CarbesteraseB.)
IPR014788 (AChE_tetra.)
IPR019819 (Carboxylesterase_B_CS.)
IPR019826 (Carboxylesterase_B_AS.)
IPR029058 (AB_hydrolase.)
Pfam PF00135 (COesterase)
PF08674 (AChE_tetra)

Target Cross References - Structure

PDBe 1C2B 1C2O 1J06 1J07 1KU6 1MAA 1MAH 1N5M 1N5R 1Q83 1Q84 2C0P 2C0Q 2GYU 2GYV 2GYW 2H9Y 2HA0 2HA2 2HA3 2HA4 2HA5 2HA6 2HA7 More...
CREDO 1C2B 1C2O 1J06 1J07 1KU6 1MAA 1MAH 1N5M 1N5R 1Q83 1Q84 2C0P 2C0Q 2GYU 2GYV 2GYW 2H9Y 2HA0 2HA2 2HA3 2HA4 2HA5 2HA6 2HA7 More...
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