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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3197
Preferred Name Muscarinic acetylcholine receptor M2
Synonyms Chrm-2 | Chrm2 | Muscarinic acetylcholine receptor M2
Organism Mus musculus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > acetylcholine receptor

Target Components

Component Description Relationship Accession
Muscarinic acetylcholine receptor M2 SINGLE PROTEIN Q9ERZ4

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2097162 Muscarinic acetylcholine receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0030425 (dendrite)
GO:0032279 (asymmetric synapse)
GO:0032280 (symmetric synapse)
GO:0043025 (neuronal cell body)
GO:0043679 (axon terminus)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0008144 (drug binding)
GO:0016907 (G-protein coupled acetylcholine receptor activity)
GO:1990763 (arrestin family protein binding)
GO Biological Process GO:0006940 (regulation of smooth muscle contraction)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007197 (adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway)
GO:0007207 (phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway)
GO:0007213 (G-protein coupled acetylcholine receptor signaling pathway)
GO:0007271 (synaptic transmission, cholinergic)
GO:0008016 (regulation of heart contraction)
GO:0009615 (response to virus)

Target Cross References - Protein

Guide to Pharmacology 14
MICAD NBK23717 (Muscarinic M2 receptor)
Reactome R-MMU-390648 (Muscarinic acetylcholine receptors.)
R-MMU-418594 (G alpha (i) signalling events.)
R-MMU-8856825 (Cargo recognition for clathrin-mediated endocytosis.)
R-MMU-8856828 (Clathrin-mediated endocytosis.)
UniProt E9Q9P0 Q9ERZ4

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000995 (Musac_Ach_rcpt.)
IPR001065 (Musac_Ach_M2_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)