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Target Report Card

Target Name and Classification

Target ID CHEMBL3189
Preferred Name Adenylate cyclase type V
Synonyms AC5 | ADCY5 | ATP pyrophosphate-lyase 5 | Adenylate cyclase type 5 | Adenylate cyclase type V | Adenylyl cyclase 5
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Adenylate cyclase type 5 SINGLE PROTEIN O95622

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2097167 Adenylate cyclase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000173175
Ensembl ENSG00000173175
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005929 (cilium)
GO:0008074 (guanylate cyclase complex, soluble)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0042995 (cell projection)
GO:0045111 (intermediate filament cytoskeleton)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004016 (adenylate cyclase activity)
GO:0004383 (guanylate cyclase activity)
GO:0005524 (ATP binding)
GO:0008179 (adenylate cyclase binding)
GO:0016829 (lyase activity)
GO:0016849 (phosphorus-oxygen lyase activity)
GO:0046872 (metal ion binding)
GO:0046982 (protein heterodimerization activity)
GO:0097110 (scaffold protein binding)
GO Biological Process GO:0001973 (adenosine receptor signaling pathway)
GO:0003091 (renal water homeostasis)
GO:0006171 (cAMP biosynthetic process)
GO:0006182 (cGMP biosynthetic process)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007190 (activation of adenylate cyclase activity)
GO:0007191 (adenylate cyclase-activating dopamine receptor signaling pathway)
GO:0007193 (adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway)
GO:0007195 (adenylate cyclase-inhibiting dopamine receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007626 (locomotory behavior)
GO:0009190 (cyclic nucleotide biosynthetic process)
GO:0034199 (activation of protein kinase A activity)
GO:0035556 (intracellular signal transduction)
GO:0050885 (neuromuscular process controlling balance)
GO:0061178 (regulation of insulin secretion involved in cellular response to glucose stimulus)
GO:0071377 (cellular response to glucagon stimulus)
GO:1904322 (cellular response to forskolin)
Wikipedia ADCY5

Target Cross References - Protein

canSAR O95622
Human Protein Atlas ENSG00000173175
Guide to Pharmacology 1282
Open Targets ENSG00000173175
PharmGKB PA24563
Reactome R-HSA-163359 (Glucagon signaling in metabolic regulation.)
R-HSA-163615 (PKA activation.)
R-HSA-164378 (PKA activation in glucagon signalling.)
R-HSA-170660 (Adenylate cyclase activating pathway.)
R-HSA-170670 (Adenylate cyclase inhibitory pathway.)
R-HSA-381676 (Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.)
R-HSA-400042 (Adrenaline,noradrenaline inhibits insulin secretion.)
R-HSA-418555 (G alpha (s) signalling events.)
R-HSA-418594 (G alpha (i) signalling events.)
R-HSA-418597 (G alpha (z) signalling events.)
R-HSA-432040 (Vasopressin regulates renal water homeostasis via Aquaporins.)
R-HSA-5610787 (Hedgehog 'off' state.)
TIMBAL Adenylyl%20Cyclase
UniProt B7Z8A6 O95622 Q7RTV7 Q8NFM3

Target Cross References - Domain

InterPro IPR001054 (A/G_cyclase.)
IPR009398 (Adcy_conserved_dom.)
IPR018297 (A/G_cyclase_CS.)
IPR029787 (Nucleotide_cyclase.)
IPR030672 (Adcy.)
IPR032628 (AC_N.)
Pfam PF00211 (Guanylate_cyc)
PF06327 (DUF1053)
PF16214 (AC_N)