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Target Report Card

Target Name and Classification

Target ID CHEMBL318
Preferred Name Adenosine A1 receptor
Synonyms Adenosine receptor A1 | Adora1
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > nucleotide-like receptor (family a gpcr) > adenosine receptor

Target Components

Component Description Relationship Accession
Adenosine receptor A1 SINGLE PROTEIN P25099

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096681 Adenosine receptors; A1 & A3 SELECTIVITY GROUP
CHEMBL2111386 Adenosine receptor PROTEIN FAMILY
CHEMBL2094131 Adenosine receptors; A1 & A2 SELECTIVITY GROUP
CHEMBL2095218 Adenosine receptors; A1 & A2a SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005886 (plasma membrane)
GO:0012505 (endomembrane system)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO:0030425 (dendrite)
GO:0030673 (axolemma)
GO:0032279 (asymmetric synapse)
GO:0042734 (presynaptic membrane)
GO:0043025 (neuronal cell body)
GO:0043195 (terminal bouton)
GO:0043197 (dendritic spine)
GO:0044297 (cell body)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO:0048786 (presynaptic active zone)
GO Molecular Function GO:0001609 (G-protein coupled adenosine receptor activity)
GO:0001664 (G-protein coupled receptor binding)
GO:0001883 (purine nucleoside binding)
GO:0004629 (phospholipase C activity)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0005515 (protein binding)
GO:0031072 (heat shock protein binding)
GO:0031683 (G-protein beta/gamma-subunit complex binding)
GO:0032795 (heterotrimeric G-protein binding)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0000186 (activation of MAPKK activity)
GO:0001659 (temperature homeostasis)
GO:0001666 (response to hypoxia)
GO:0001973 (adenosine receptor signaling pathway)
GO:0002087 (regulation of respiratory gaseous exchange by neurological system process)
GO:0002674 (negative regulation of acute inflammatory response)
GO:0002686 (negative regulation of leukocyte migration)
GO:0002793 (positive regulation of peptide secretion)
GO:0003093 (regulation of glomerular filtration)
GO:0006612 (protein targeting to membrane)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007193 (adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway)
GO:0008285 (negative regulation of cell proliferation)
GO:0014050 (negative regulation of glutamate secretion)
GO:0016042 (lipid catabolic process)
GO:0032229 (negative regulation of synaptic transmission, GABAergic)
GO:0032244 (positive regulation of nucleoside transport)
GO:0032900 (negative regulation of neurotrophin production)
GO:0035307 (positive regulation of protein dephosphorylation)
GO:0035814 (negative regulation of renal sodium excretion)
GO:0042312 (regulation of vasodilation)
GO:0042321 (negative regulation of circadian sleep/wake cycle, sleep)
GO:0042323 (negative regulation of circadian sleep/wake cycle, non-REM sleep)
GO:0043066 (negative regulation of apoptotic process)
GO:0043268 (positive regulation of potassium ion transport)
GO:0045741 (positive regulation of epidermal growth factor-activated receptor activity)
GO:0045776 (negative regulation of blood pressure)
GO:0045777 (positive regulation of blood pressure)
GO:0045822 (negative regulation of heart contraction)
GO:0045908 (negative regulation of vasodilation)
GO:0046888 (negative regulation of hormone secretion)
GO:0048167 (regulation of synaptic plasticity)
GO:0050728 (negative regulation of inflammatory response)
GO:0050890 (cognition)
GO:0050965 (detection of temperature stimulus involved in sensory perception of pain)
GO:0050995 (negative regulation of lipid catabolic process)
GO:0051930 (regulation of sensory perception of pain)
GO:0051967 (negative regulation of synaptic transmission, glutamatergic)
GO:0055117 (regulation of cardiac muscle contraction)
GO:0055118 (negative regulation of cardiac muscle contraction)
GO:0060079 (excitatory postsynaptic potential)
GO:0060087 (relaxation of vascular smooth muscle)
GO:0070256 (negative regulation of mucus secretion)
GO:1900453 (negative regulation of long term synaptic depression)

Target Cross References - Protein

canSAR P25099
IntAct P25099
Guide to Pharmacology 18
MICAD NBK23601 (Adenosine A1 receptor)
NBK23624 (Adenosine A1 receptor)
Reactome R-RNO-417973 (Adenosine P1 receptors.)
R-RNO-418594 (G alpha (i) signalling events.)
UniProt P25099

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR001068 (Adeno_A1_rcpt.)
IPR001634 (Adenosn_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)