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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3159
Target Type SINGLE PROTEIN
Preferred Name Trypsin II
Synonyms Anionic trypsinogen | PRSS2 | Serine protease 2 | TRY2 | TRYP2 | Trypsin II | Trypsin-2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease pa clan > serine protease s1a subfamily

Target Components

Component Description Relationship Accession
Trypsin-2 SINGLE PROTEIN P07478

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095204 Trypsin PROTEIN FAMILY
CHEMBL2096988 Thrombin & trypsin SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000275896 ENSG00000282049
Ensembl ENSG00000275896 ENSG00000282049
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0031012 (extracellular matrix)
GO:0035578 (azurophil granule lumen)
GO Molecular Function GO:0004222 (metalloendopeptidase activity)
GO:0004252 (serine-type endopeptidase activity)
GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008236 (serine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006508 (proteolysis)
GO:0007586 (digestion)
GO:0019730 (antimicrobial humoral response)
GO:0022617 (extracellular matrix disassembly)
GO:0030307 (positive regulation of cell growth)
GO:0030574 (collagen catabolic process)
GO:0043312 (neutrophil degranulation)
GO:0045785 (positive regulation of cell adhesion)

Target Cross References - Protein

canSAR P07478
Human Protein Atlas ENSG00000275896 ENSG00000282049
IntAct P07478
Open Targets ENSG00000275896 ENSG00000282049
PharmGKB PA33833
Reactome R-HSA-1442490 (Collagen degradation.)
R-HSA-1462054 (Alpha-defensins.)
R-HSA-1592389 (Activation of Matrix Metalloproteinases.)
R-HSA-6798695 (Neutrophil degranulation.)
R-HSA-6803157 (Antimicrobial peptides.)
UniProt P07478

Target Cross References - Domain

InterPro IPR001254 (Trypsin_dom.)
IPR001314 (Peptidase_S1A.)
IPR009003 (Peptidase_S1_PA.)
IPR018114 (TRYPSIN_HIS.)
IPR033116 (TRYPSIN_SER.)
Pfam PF00089 (Trypsin)
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