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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL315
Preferred Name Alpha-1b adrenergic receptor
Synonyms Adra1b | Alpha-1B adrenergic receptor | Alpha-1B adrenoceptor | Alpha-1B adrenoreceptor
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > adrenergic receptor

Target Components

Component Description Relationship Accession
Alpha-1B adrenergic receptor SINGLE PROTEIN P15823

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL1907610 Adrenergic receptor alpha-1 PROTEIN FAMILY
CHEMBL2097171 Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 SELECTIVITY GROUP
CHEMBL2094111 Adrenergic receptor alpha PROTEIN FAMILY
CHEMBL2111476 Alpha adrenergic receptor 1A and 1B SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005901 (caveola)
GO:0014704 (intercalated disc)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030315 (T-tubule)
GO:0031965 (nuclear membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004935 (adrenergic receptor activity)
GO:0004937 (alpha1-adrenergic receptor activity)
GO:0005515 (protein binding)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0001994 (norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure)
GO:0006937 (regulation of muscle contraction)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007267 (cell-cell signaling)
GO:0009725 (response to hormone)
GO:0019229 (regulation of vasoconstriction)
GO:0035024 (negative regulation of Rho protein signal transduction)
GO:0042493 (response to drug)
GO:0042593 (glucose homeostasis)
GO:0043410 (positive regulation of MAPK cascade)
GO:0043627 (response to estrogen)
GO:0045907 (positive regulation of vasoconstriction)
GO:0045987 (positive regulation of smooth muscle contraction)
GO:0048545 (response to steroid hormone)
GO:0055117 (regulation of cardiac muscle contraction)
GO:0071880 (adenylate cyclase-activating adrenergic receptor signaling pathway)

Target Cross References - Protein

canSAR P15823
IntAct P15823
Guide to Pharmacology 23
UniProt P15823 Q63215

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR001115 (ADRA1B_rcpt.)
IPR002233 (ADR_fam.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)