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Target Report Card

Target Name and Classification

Target ID CHEMBL3145
Preferred Name PI3-kinase p110-beta subunit
Synonyms PI3-kinase subunit beta | PI3K-beta | PI3Kbeta | PIK3C1 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | PtdIns-3-kinase subunit beta | PtdIns-3-kinase subunit p110-beta | p110beta
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform SINGLE PROTEIN P42338

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038510 PI3K p110 beta/p85 alpha PROTEIN COMPLEX
CHEMBL3885615 Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3188551 GSK-2636771 PI3-kinase p110-beta subunit inhibitor 2 PubMed PubMed
CHEMBL3622533 FIMEPINOSTAT PI3-kinase p110-beta subunit inhibitor 2 Other PubMed
CHEMBL3545008 SAR-260301 PI3-kinase p110-beta subunit inhibitor 1 PubMed
CHEMBL3545245 BAY-1082439 PI3-kinase p110-beta subunit inhibitor 1 Other
CHEMBL3545424 AZD-8186 PI3-kinase p110-beta subunit inhibitor 1 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000051382
Ensembl ENSG00000051382
GO Cellular Component GO:0005634 (nucleus)
GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005942 (phosphatidylinositol 3-kinase complex)
GO:0030496 (midbody)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016303 (1-phosphatidylinositol-3-kinase activity)
GO:0016740 (transferase activity)
GO:0035004 (phosphatidylinositol 3-kinase activity)
GO:0035005 (1-phosphatidylinositol-4-phosphate 3-kinase activity)
GO:0043560 (insulin receptor substrate binding)
GO:0046934 (phosphatidylinositol-4,5-bisphosphate 3-kinase activity)
GO Biological Process GO:0000187 (activation of MAPK activity)
GO:0001935 (endothelial cell proliferation)
GO:0001952 (regulation of cell-matrix adhesion)
GO:0002250 (adaptive immune response)
GO:0006661 (phosphatidylinositol biosynthetic process)
GO:0006874 (cellular calcium ion homeostasis)
GO:0006897 (endocytosis)
GO:0006914 (autophagy)
GO:0006935 (chemotaxis)
GO:0006954 (inflammatory response)
GO:0007155 (cell adhesion)
GO:0007156 (homophilic cell adhesion via plasma membrane adhesion molecules)
GO:0007165 (signal transduction)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007411 (axon guidance)
GO:0009611 (response to wounding)
GO:0010508 (positive regulation of autophagy)
GO:0010628 (positive regulation of gene expression)
GO:0014065 (phosphatidylinositol 3-kinase signaling)
GO:0016310 (phosphorylation)
GO:0016477 (cell migration)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0030168 (platelet activation)
GO:0033031 (positive regulation of neutrophil apoptotic process)
GO:0036092 (phosphatidylinositol-3-phosphate biosynthetic process)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0038096 (Fc-gamma receptor signaling pathway involved in phagocytosis)
GO:0040016 (embryonic cleavage)
GO:0045087 (innate immune response)
GO:0046854 (phosphatidylinositol phosphorylation)
GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
GO:0048015 (phosphatidylinositol-mediated signaling)
GO:0050852 (T cell receptor signaling pathway)
GO:0050900 (leukocyte migration)
GO:0051897 (positive regulation of protein kinase B signaling)
GO:0060055 (angiogenesis involved in wound healing)
GO:0060326 (cell chemotaxis)
GO:0070527 (platelet aggregation)
GO:2000369 (regulation of clathrin-mediated endocytosis)
Wikipedia PIK3CB

Target Cross References - Protein

canSAR P42338
Human Protein Atlas ENSG00000051382
IntAct P42338
Guide to Pharmacology 2154
Open Targets ENSG00000051382
PharmGKB PA33309
Pharos P42338 (Tchem)
Reactome R-HSA-109704 (PI3K Cascade.)
R-HSA-114604 (GPVI-mediated activation cascade.)
R-HSA-1257604 (PIP3 activates AKT signaling.)
R-HSA-1660499 (Synthesis of PIPs at the plasma membrane.)
R-HSA-186763 (Downstream signal transduction.)
R-HSA-198203 (PI3K/AKT activation.)
R-HSA-202424 (Downstream TCR signaling.)
R-HSA-2029485 (Role of phospholipids in phagocytosis.)
R-HSA-210993 (Tie2 Signaling.)
R-HSA-2219530 (Constitutive Signaling by Aberrant PI3K in Cancer.)
R-HSA-2424491 (DAP12 signaling.)
R-HSA-2730905 (Role of LAT2/NTAL/LAB on calcium mobilization.)
R-HSA-373753 (Nephrin family interactions.)
R-HSA-392451 (G beta:gamma signalling through PI3Kgamma.)
R-HSA-4420097 (VEGFA-VEGFR2 Pathway.)
R-HSA-512988 (Interleukin-3, 5 and GM-CSF signaling.)
R-HSA-6811558 (PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.)
R-HSA-8853659 (RET signaling.)
R-HSA-912526 (Interleukin receptor SHC signaling.)
R-HSA-912631 (Regulation of signaling by CBL.)
UniProt D3DNF0 P42338 Q24JU2

Target Cross References - Domain

InterPro IPR000341 (PI3K_Ras-bd_dom.)
IPR000403 (PI3/4_kinase_cat_dom.)
IPR001263 (PInositide-3_kin_accessory_dom.)
IPR002420 (PI3K_C2_dom.)
IPR003113 (PI3K_adapt-bd_dom.)
IPR008290 (PI3K_Vps34.)
IPR011009 (Kinase-like_dom_sf.)
IPR015433 (PI_Kinase.)
IPR016024 (ARM-type_fold.)
IPR018936 (PI3/4_kinase_CS.)
IPR029071 (Ubiquitin-like_domsf.)
IPR035892 (C2_domain_sf.)
IPR036940 (PI3/4_kinase_cat_sf.)
IPR037702 (PI3Kbeta_dom.)
Pfam PF00454 (PI3_PI4_kinase)
PF00613 (PI3Ka)
PF00792 (PI3K_C2)
PF00794 (PI3K_rbd)
PF02192 (PI3K_p85B)