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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL314
Preferred Name Alpha-2c adrenergic receptor
Synonyms Adra2c | Alpha-2 adrenergic receptor subtype C4 | Alpha-2C adrenergic receptor | Alpha-2C adrenoceptor | Alpha-2C adrenoreceptor | Alpha-2CAR
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > adrenergic receptor

Target Components

Component Description Relationship Accession
Alpha-2C adrenergic receptor SINGLE PROTEIN P22086

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094111 Adrenergic receptor alpha PROTEIN FAMILY
CHEMBL2093864 Adrenergic receptor alpha-2 PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030424 (axon)
GO:0043679 (axon terminus)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004935 (adrenergic receptor activity)
GO:0004938 (alpha2-adrenergic receptor activity)
GO:0031694 (alpha-2A adrenergic receptor binding)
GO:0042803 (protein homodimerization activity)
GO:0046982 (protein heterodimerization activity)
GO:0051379 (epinephrine binding)
GO Biological Process GO:0006940 (regulation of smooth muscle contraction)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007267 (cell-cell signaling)
GO:0007565 (female pregnancy)
GO:0019229 (regulation of vasoconstriction)
GO:0030168 (platelet activation)
GO:0032148 (activation of protein kinase B activity)
GO:0035625 (epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway)
GO:0043410 (positive regulation of MAPK cascade)
GO:0045666 (positive regulation of neuron differentiation)
GO:0045907 (positive regulation of vasoconstriction)
GO:0051930 (regulation of sensory perception of pain)
GO:0070473 (negative regulation of uterine smooth muscle contraction)
GO:0071875 (adrenergic receptor signaling pathway)
GO:0071880 (adenylate cyclase-activating adrenergic receptor signaling pathway)

Target Cross References - Protein

canSAR P22086
Reactome R-RNO-390696 (Adrenoceptors.)
R-RNO-392023 (Adrenaline signalling through Alpha-2 adrenergic receptor.)
R-RNO-400042 (Adrenaline,noradrenaline inhibits insulin secretion.)
R-RNO-418594 (G alpha (i) signalling events.)
R-RNO-418597 (G alpha (z) signalling events.)
R-RNO-5683826 (Surfactant metabolism.)
UniProt P22086

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000735 (ADRA2C_rcpt.)
IPR002233 (ADR_fam.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)