ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL3138
Target Type SINGLE PROTEIN
Preferred Name Dopamine D3 receptor
Synonyms D(3) dopamine receptor | Dopamine D3 receptor | Drd3
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > dopamine receptor

Target Components

Component Description Relationship Accession
D(3) dopamine receptor SINGLE PROTEIN P19020

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111342 Dopamine receptor D2 and D3 SELECTIVITY GROUP
CHEMBL2093868 Dopamine receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030139 (endocytic vesicle)
GO:0042995 (cell projection)
GO:0045177 (apical part of cell)
GO Molecular Function GO:0001591 (dopamine neurotransmitter receptor activity, coupled via Gi/Go)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004952 (dopamine neurotransmitter receptor activity)
GO:0005515 (protein binding)
GO:0008144 (drug binding)
GO:0019904 (protein domain specific binding)
GO:0031748 (D1 dopamine receptor binding)
GO:0035240 (dopamine binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001963 (synaptic transmission, dopaminergic)
GO:0001975 (response to amphetamine)
GO:0002016 (regulation of blood volume by renin-angiotensin)
GO:0002031 (G-protein coupled receptor internalization)
GO:0006874 (cellular calcium ion homeostasis)
GO:0006914 (autophagy)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007191 (adenylate cyclase-activating dopamine receptor signaling pathway)
GO:0007195 (adenylate cyclase-inhibiting dopamine receptor signaling pathway)
GO:0007212 (dopamine receptor signaling pathway)
GO:0007626 (locomotory behavior)
GO:0008284 (positive regulation of cell proliferation)
GO:0008542 (visual learning)
GO:0014059 (regulation of dopamine secretion)
GO:0019216 (regulation of lipid metabolic process)
GO:0030814 (regulation of cAMP metabolic process)
GO:0032416 (negative regulation of sodium:proton antiporter activity)
GO:0032467 (positive regulation of cytokinesis)
GO:0032922 (circadian regulation of gene expression)
GO:0034776 (response to histamine)
GO:0035483 (gastric emptying)
GO:0035815 (positive regulation of renal sodium excretion)
GO:0040012 (regulation of locomotion)
GO:0040014 (regulation of multicellular organism growth)
GO:0042220 (response to cocaine)
GO:0042493 (response to drug)
GO:0043066 (negative regulation of apoptotic process)
GO:0043278 (response to morphine)
GO:0045187 (regulation of circadian sleep/wake cycle, sleep)
GO:0045471 (response to ethanol)
GO:0045776 (negative regulation of blood pressure)
GO:0045840 (positive regulation of mitotic nuclear division)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046717 (acid secretion)
GO:0048148 (behavioral response to cocaine)
GO:0048715 (negative regulation of oligodendrocyte differentiation)
GO:0050482 (arachidonic acid secretion)
GO:0050709 (negative regulation of protein secretion)
GO:0050883 (musculoskeletal movement, spinal reflex action)
GO:0051898 (negative regulation of protein kinase B signaling)
GO:0060134 (prepulse inhibition)
GO:0060160 (negative regulation of dopamine receptor signaling pathway)
GO:0060161 (positive regulation of dopamine receptor signaling pathway)
GO:0090325 (regulation of locomotion involved in locomotory behavior)

Target Cross References - Protein

canSAR P19020
Guide to Pharmacology 216
MICAD NBK50682 (D3 dopamine receptors)
Reactome R-RNO-390651 (Dopamine receptors.)
R-RNO-418594 (G alpha (i) signalling events.)
UniProt P19020 P70647

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000929 (Dopamine_rcpt.)
IPR001620 (Dopamine_D3_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
spacer
spacer