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Target Report Card

Target Name and Classification

Target ID CHEMBL3136
Preferred Name Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
Synonyms ATP2A1 | Calcium pump 1 | Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform | Endoplasmic reticulum class 1/2 Ca(2+) ATPase | SERCA1 | SR Ca(2+)-ATPase 1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > primary active transporter > p-type atpase > calcium atpase
  • enzyme > hydrolase

Target Components

Component Description Relationship Accession
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 SINGLE PROTEIN O14983

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000196296
Ensembl ENSG00000196296
GO Cellular Component GO:0005739 (mitochondrion)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005793 (endoplasmic reticulum-Golgi intermediate compartment)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016529 (sarcoplasmic reticulum)
GO:0031095 (platelet dense tubular network membrane)
GO:0031673 (H zone)
GO:0031674 (I band)
GO:0033017 (sarcoplasmic reticulum membrane)
GO:0034704 (calcium channel complex)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0005388 (calcium-transporting ATPase activity)
GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016787 (hydrolase activity)
GO:0042803 (protein homodimerization activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006816 (calcium ion transport)
GO:0006942 (regulation of striated muscle contraction)
GO:0008637 (apoptotic mitochondrial changes)
GO:0031448 (positive regulation of fast-twitch skeletal muscle fiber contraction)
GO:0032470 (positive regulation of endoplasmic reticulum calcium ion concentration)
GO:0032471 (negative regulation of endoplasmic reticulum calcium ion concentration)
GO:0034220 (ion transmembrane transport)
GO:0034976 (response to endoplasmic reticulum stress)
GO:0045988 (negative regulation of striated muscle contraction)
GO:0051561 (positive regulation of mitochondrial calcium ion concentration)
GO:0051659 (maintenance of mitochondrion location)
GO:0070059 (intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)
GO:0070509 (calcium ion import)
GO:0070588 (calcium ion transmembrane transport)
GO:0090076 (relaxation of skeletal muscle)
GO:1903779 (regulation of cardiac conduction)
Wikipedia ATP2A1

Target Cross References - Protein

canSAR O14983
CGD Brody myopathy
Human Protein Atlas ENSG00000196296
IntAct O14983
Guide to Pharmacology 840
Open Targets ENSG00000196296
PharmGKB PA25105
Reactome R-HSA-1912420 (Pre-NOTCH Processing in Golgi.)
R-HSA-418359 (Reduction of cytosolic Ca++ levels.)
R-HSA-5578775 (Ion homeostasis.)
R-HSA-936837 (Ion transport by P-type ATPases.)
UniProt A8K5J9 B3KY17 O14983 O14984

Target Cross References - Domain

InterPro IPR001757 (P_typ_ATPase.)
IPR004014 (ATPase_P-typ_cation-transptr_N.)
IPR005782 (P-type_ATPase_IIA.)
IPR006068 (ATPase_P-typ_cation-transptr_C.)
IPR008250 (ATPase_P-typ_transduc_dom_A.)
IPR018303 (ATPase_P-typ_P_site.)
IPR023214 (HAD-like_dom.)
IPR023298 (ATPase_P-typ_TM_dom.)
IPR023299 (ATPase_P-typ_cyto_domN.)
IPR030332 (SERCA1.)
Pfam PF00122 (E1-E2_ATPase)
PF00689 (Cation_ATPase_C)
PF00690 (Cation_ATPase_N)
PF08282 (Hydrolase_3)