ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL3125
Preferred Name Ribosomal protein S6 kinase alpha 4
Synonyms 90 kDa ribosomal protein S6 kinase 4 | MSK2 | Nuclear mitogen- and stress-activated protein kinase 2 | RPS6KA4 | RSKB | Ribosomal protein S6 kinase alpha-4 | Ribosomal protein kinase B | S6K-alpha-4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase rskb family > camk protein kinase mskb subfamily
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase rsk family > agc protein kinase msk subfamily

Target Components

Component Description Relationship Accession
Ribosomal protein S6 kinase alpha-4 SINGLE PROTEIN O75676

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3832633 Ribosomal protein S6 kinase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000162302
Ensembl ENSG00000162302
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004711 (ribosomal protein S6 kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001818 (negative regulation of cytokine production)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006468 (protein phosphorylation)
GO:0006954 (inflammatory response)
GO:0016310 (phosphorylation)
GO:0016572 (histone phosphorylation)
GO:0032793 (positive regulation of CREB transcription factor activity)
GO:0033129 (positive regulation of histone phosphorylation)
GO:0035066 (positive regulation of histone acetylation)
GO:0035556 (intracellular signal transduction)
GO:0043987 (histone H3-S10 phosphorylation)
GO:0043988 (histone H3-S28 phosphorylation)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0070498 (interleukin-1-mediated signaling pathway)
Wikipedia RPS6KA4

Target Cross References - Protein

canSAR O75676
Human Protein Atlas ENSG00000162302
IntAct O75676
Guide to Pharmacology 1524
Open Targets ENSG00000162302
PharmGKB PA34848
Pharos O75676 (Tchem)
Reactome R-HSA-437239 (Recycling pathway of L1.)
UniProt A8K7Z8 O75585 O75676 Q53ES8

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR016239 (Ribosomal_S6_kinase_II.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017892 (Pkinase_C.)
IPR037714 (MSK2_N_dom.)
Pfam PF00069 (Pkinase)
PF00433 (Pkinase_C)