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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3120
Target Type SINGLE PROTEIN
Preferred Name Asparagine synthetase
Synonyms ASNS | Asparagine synthetase [glutamine-hydrolyzing] | Cell cycle control protein TS11 | Glutamine-dependent asparagine synthetase | TS11
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Asparagine synthetase [glutamine-hydrolyzing] SINGLE PROTEIN P08243

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000070669
Ensembl ENSG00000070669
GO Cellular Component GO:0005829 (cytosol)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004066 (asparagine synthase (glutamine-hydrolyzing) activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016874 (ligase activity)
GO:0042803 (protein homodimerization activity)
GO:0048037 (cofactor binding)
GO Biological Process GO:0001889 (liver development)
GO:0006520 (cellular amino acid metabolic process)
GO:0006529 (asparagine biosynthetic process)
GO:0006541 (glutamine metabolic process)
GO:0008652 (cellular amino acid biosynthetic process)
GO:0009416 (response to light stimulus)
GO:0009612 (response to mechanical stimulus)
GO:0009636 (response to toxic substance)
GO:0031427 (response to methotrexate)
GO:0031667 (response to nutrient levels)
GO:0032354 (response to follicle-stimulating hormone)
GO:0032870 (cellular response to hormone stimulus)
GO:0036499 (PERK-mediated unfolded protein response)
GO:0042149 (cellular response to glucose starvation)
GO:0043066 (negative regulation of apoptotic process)
GO:0043200 (response to amino acid)
GO:0045931 (positive regulation of mitotic cell cycle)
GO:0070981 (L-asparagine biosynthetic process)

Target Cross References - Protein

canSAR P08243
Human Protein Atlas ENSG00000070669
IntAct P08243
Open Targets ENSG00000070669
PharmGKB PA25052
Reactome R-HSA-380994 (ATF4 activates genes.)
R-HSA-70614 (Amino acid synthesis and interconversion (transamination).)
UniProt A4D1I8 B4DXZ1 B7ZAA9 D6W5R3 E9PCI3 E9PCX6 P08184 P08243 Q15666 Q549T9 Q96HD0

Target Cross References - Domain

InterPro IPR001962 (Asn_synthase.)
IPR006426 (Asn_synth_AEB.)
IPR014729 (Rossmann-like_a/b/a_fold.)
IPR017932 (GATase_2_dom.)
IPR029055 (Ntn_hydrolases_N.)
IPR033738 (AsnB_N.)
Pfam PF00733 (Asn_synthase)
PF13537 (GATase_7)
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