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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL312
Preferred Name Arachidonate 5-lipoxygenase
Synonyms 5-LO | 5-lipoxygenase | Alox5 | Arachidonate 5-lipoxygenase
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme > oxidoreductase

Target Components

Component Description Relationship Accession
Arachidonate 5-lipoxygenase SINGLE PROTEIN P12527

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005635 (nuclear envelope)
GO:0005641 (nuclear envelope lumen)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO:0016363 (nuclear matrix)
GO:0030425 (dendrite)
GO:0031965 (nuclear membrane)
GO:0042383 (sarcolemma)
GO Molecular Function GO:0004051 (arachidonate 5-lipoxygenase activity)
GO:0005506 (iron ion binding)
GO:0005515 (protein binding)
GO:0016491 (oxidoreductase activity)
GO:0016702 (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)
GO:0046872 (metal ion binding)
GO:0051213 (dioxygenase activity)
GO Biological Process GO:0002526 (acute inflammatory response)
GO:0007584 (response to nutrient)
GO:0019233 (sensory perception of pain)
GO:0019369 (arachidonic acid metabolic process)
GO:0019370 (leukotriene biosynthetic process)
GO:0019372 (lipoxygenase pathway)
GO:0045907 (positive regulation of vasoconstriction)
GO:0055093 (response to hyperoxia)
GO:0055114 (oxidation-reduction process)

Target Cross References - Protein

canSAR P12527
IntAct P12527
UniProt P12527

Target Cross References - Domain

InterPro IPR000907 (LipOase.)
IPR001024 (PLAT/LH2_dom.)
IPR001885 (LipOase_mml.)
IPR013819 (LipOase_C.)
IPR020833 (LipOase_Fe_BS.)
IPR020834 (LipOase_CS.)
IPR036226 (LipOase_C_sf.)
IPR036392 (PLAT/LH2_dom_sf.)
Pfam PF00305 (Lipoxygenase)
PF01477 (PLAT)