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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL310
Target Type SINGLE PROTEIN
Preferred Name Glutamate [NMDA] receptor subunit epsilon 1
Synonyms GluN2A | Glutamate [NMDA] receptor subunit epsilon-1 | Glutamate receptor ionotropic, NMDA 2A | Grin2a | N-methyl D-aspartate receptor subtype 2A | NMDAR2A | NR2A
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > ionotropic glutamate receptor > nmda receptor

Target Components

Component Description Relationship Accession
Glutamate receptor ionotropic, NMDA 2A SINGLE PROTEIN Q00959

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096680 Glutamate NMDA receptor; Grin1/Grin2a PROTEIN COMPLEX
CHEMBL2096669 Glutamate receptors; NMDA/AMPA PROTEIN COMPLEX GROUP
CHEMBL1907608 Glutamate NMDA receptor PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0017146 (NMDA selective glutamate receptor complex)
GO:0030054 (cell junction)
GO:0042734 (presynaptic membrane)
GO:0043005 (neuron projection)
GO:0043195 (terminal bouton)
GO:0043197 (dendritic spine)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004970 (ionotropic glutamate receptor activity)
GO:0004972 (NMDA glutamate receptor activity)
GO:0005102 (receptor binding)
GO:0005216 (ion channel activity)
GO:0005234 (extracellular-glutamate-gated ion channel activity)
GO:0005261 (cation channel activity)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0016595 (glutamate binding)
GO:0019901 (protein kinase binding)
GO:0022843 (voltage-gated cation channel activity)
GO:0022849 (glutamate-gated calcium ion channel activity)
GO:0035254 (glutamate receptor binding)
GO:0038023 (signaling receptor activity)
GO:0042165 (neurotransmitter binding)
GO:0044877 (macromolecular complex binding)
GO:0046872 (metal ion binding)
GO:0046982 (protein heterodimerization activity)
GO:0046983 (protein dimerization activity)
GO:0050839 (cell adhesion molecule binding)
GO:0051117 (ATPase binding)
GO:0097110 (scaffold protein binding)
GO Biological Process GO:0001508 (action potential)
GO:0006811 (ion transport)
GO:0007268 (chemical synaptic transmission)
GO:0007613 (memory)
GO:0009416 (response to light stimulus)
GO:0009743 (response to carbohydrate)
GO:0010042 (response to manganese ion)
GO:0010942 (positive regulation of cell death)
GO:0014070 (response to organic cyclic compound)
GO:0014075 (response to amine)
GO:0019722 (calcium-mediated signaling)
GO:0021510 (spinal cord development)
GO:0021766 (hippocampus development)
GO:0021987 (cerebral cortex development)
GO:0035235 (ionotropic glutamate receptor signaling pathway)
GO:0042220 (response to cocaine)
GO:0042493 (response to drug)
GO:0045471 (response to ethanol)
GO:0048169 (regulation of long-term neuronal synaptic plasticity)
GO:0048511 (rhythmic process)
GO:0051262 (protein tetramerization)
GO:0051592 (response to calcium ion)
GO:0051597 (response to methylmercury)
GO:0051707 (response to other organism)
GO:0060079 (excitatory postsynaptic potential)
GO:0060359 (response to ammonium ion)
GO:0060992 (response to fungicide)
GO:0071230 (cellular response to amino acid stimulus)
GO:0071286 (cellular response to magnesium ion)
GO:0071287 (cellular response to manganese ion)
GO:0071294 (cellular response to zinc ion)
GO:0071359 (cellular response to dsRNA)
GO:0071363 (cellular response to growth factor stimulus)
GO:0071396 (cellular response to lipid)
GO:0097553 (calcium ion transmembrane import into cytosol)
GO:2000463 (positive regulation of excitatory postsynaptic potential)

Target Cross References - Protein

canSAR Q00959
IntAct Q00959
UniProt O08948 Q00959 Q63728

Target Cross References - Domain

InterPro IPR001320 (Iontro_rcpt.)
IPR001508 (Iono_rcpt_met.)
IPR001828 (ANF_lig-bd_rcpt.)
IPR018884 (NMDAR2_C.)
IPR019594 (Glu/Gly-bd.)
IPR028082 (Peripla_BP_I.)
Pfam PF00060 (Lig_chan)
PF01094 (ANF_receptor)
PF10565 (NMDAR2_C)
PF10613 (Lig_chan-Glu_bd)

Target Cross References - Structure

PDBe 2A5S 2A5T 4JWX 4NF4 4NF5 4NF6 4NF8 5DEX 5I56 5I57 5I58 5I59 5JTY 5TPW 5TQ0 5TQ2 5U8C 5VIH 5VII 5VIJ
CREDO 2A5S 2A5T 4JWX 4NF4 4NF5 4NF6 4NF8 5DEX 5I56 5I57 5I58 5I59 5JTY 5TPW 5TQ0 5TQ2 5U8C 5VIH 5VII 5VIJ
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