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ChEMBL

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Target Report Card

Target Name and Classification

Target ID CHEMBL3099
Target Type SINGLE PROTEIN
Preferred Name Tyrosine-protein kinase ABL
Synonyms Abelson murine leukemia viral oncogene homolog 1 | Abelson tyrosine-protein kinase 1 | Abl | Abl1 | Proto-oncogene c-Abl | Tyrosine-protein kinase ABL1 | p150
Organism Mus musculus
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase abl family

Target Components

Component Description Relationship Accession
Tyrosine-protein kinase ABL1 SINGLE PROTEIN P00520

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0015629 (actin cytoskeleton)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO:0031252 (cell leading edge)
GO:0043005 (neuron projection)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0003677 (DNA binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005080 (protein kinase C binding)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008022 (protein C-terminus binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0017124 (SH3 domain binding)
GO:0019904 (protein domain specific binding)
GO:0019905 (syntaxin binding)
GO:0030145 (manganese ion binding)
GO:0046872 (metal ion binding)
GO:0051015 (actin filament binding)
GO:0051019 (mitogen-activated protein kinase binding)
GO:0070064 (proline-rich region binding)
GO Biological Process GO:0001922 (B-1 B cell homeostasis)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0002322 (B cell proliferation involved in immune response)
GO:0002333 (transitional one stage B cell differentiation)
GO:0006281 (DNA repair)
GO:0006468 (protein phosphorylation)
GO:0006897 (endocytosis)
GO:0006909 (phagocytosis)
GO:0006914 (autophagy)
GO:0006915 (apoptotic process)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0006975 (DNA damage induced protein phosphorylation)
GO:0006979 (response to oxidative stress)
GO:0007155 (cell adhesion)
GO:0007173 (epidermal growth factor receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007596 (blood coagulation)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0021587 (cerebellum morphogenesis)
GO:0022408 (negative regulation of cell-cell adhesion)
GO:0030035 (microspike assembly)
GO:0030036 (actin cytoskeleton organization)
GO:0030514 (negative regulation of BMP signaling pathway)
GO:0030516 (regulation of axon extension)
GO:0031113 (regulation of microtubule polymerization)
GO:0032956 (regulation of actin cytoskeleton organization)
GO:0033690 (positive regulation of osteoblast proliferation)
GO:0034446 (substrate adhesion-dependent cell spreading)
GO:0035791 (platelet-derived growth factor receptor-beta signaling pathway)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0042100 (B cell proliferation)
GO:0042770 (signal transduction in response to DNA damage)
GO:0043065 (positive regulation of apoptotic process)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0043124 (negative regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0045087 (innate immune response)
GO:0045184 (establishment of protein localization)
GO:0045930 (negative regulation of mitotic cell cycle)
GO:0045931 (positive regulation of mitotic cell cycle)
GO:0046632 (alpha-beta T cell differentiation)
GO:0046777 (protein autophosphorylation)
GO:0048008 (platelet-derived growth factor receptor signaling pathway)
GO:0048536 (spleen development)
GO:0048538 (thymus development)
GO:0048668 (collateral sprouting)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0050798 (activated T cell proliferation)
GO:0050853 (B cell receptor signaling pathway)
GO:0050885 (neuromuscular process controlling balance)
GO:0051149 (positive regulation of muscle cell differentiation)
GO:0051281 (positive regulation of release of sequestered calcium ion into cytosol)
GO:0051353 (positive regulation of oxidoreductase activity)
GO:0051444 (negative regulation of ubiquitin-protein transferase activity)
GO:0051726 (regulation of cell cycle)
GO:0060020 (Bergmann glial cell differentiation)
GO:0070301 (cellular response to hydrogen peroxide)
GO:0070373 (negative regulation of ERK1 and ERK2 cascade)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0071222 (cellular response to lipopolysaccharide)
GO:0071901 (negative regulation of protein serine/threonine kinase activity)
GO:0090135 (actin filament branching)
GO:1900042 (positive regulation of interleukin-2 secretion)
GO:1900275 (negative regulation of phospholipase C activity)
GO:1901216 (positive regulation of neuron death)
GO:1902715 (positive regulation of interferon-gamma secretion)
GO:1903053 (regulation of extracellular matrix organization)
GO:1904528 (positive regulation of microtubule binding)
GO:1904531 (positive regulation of actin filament binding)
GO:1990051 (activation of protein kinase C activity)
GO:2000096 (positive regulation of Wnt signaling pathway, planar cell polarity pathway)
GO:2000352 (negative regulation of endothelial cell apoptotic process)
GO:2000772 (regulation of cellular senescence)
GO:2000773 (negative regulation of cellular senescence)
GO:2001020 (regulation of response to DNA damage stimulus)

Target Cross References - Protein

canSAR P00520
IntAct P00520
Reactome R-MMU-2029482 (Regulation of actin dynamics for phagocytic cup formation.)
R-MMU-375170 (CDO in myogenesis.)
R-MMU-428890 (Role of Abl in Robo-Slit signaling.)
R-MMU-5663213 (RHO GTPases Activate WASPs and WAVEs.)
R-MMU-5685938 (HDR through Single Strand Annealing (SSA).)
R-MMU-5693565 (Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.)
R-MMU-983231 (Factors involved in megakaryocyte development and platelet production.)
UniProt P00520 P97896 Q61252 Q61253 Q61254 Q61255 Q61256 Q61257 Q61258 Q61259 Q61260 Q61261 Q6PCM5 Q8C1X4

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001452 (SH3_domain.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR015015 (F-actin_binding.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR033221 (ABL1.)
Pfam PF00017 (SH2)
PF00018 (SH3_1)
PF07714 (Pkinase_Tyr)
PF08919 (F_actin_bind)

Target Cross References - Structure

PDBe 1ABO 1ABQ 1FPU 1IEP 1M52 1OPJ 1OPK 2HZN 2QOH 2Z60 3DK3 3DK6 3DK7 3IK3 3K5V 3KF4 3KFA 3MS9 3MSS 3OXZ 3OY3 5IH2
CREDO 1ABO 1ABQ 1FPU 1IEP 1M52 1OPJ 1OPK 2HZN 2QOH 2Z60 3DK3 3DK6 3DK7 3IK3 3K5V 3KF4 3KFA 3MS9 3MSS 3OXZ 3OY3 5IH2
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