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Target Report Card

Target Name and Classification

Target ID CHEMBL3099
Preferred Name Tyrosine-protein kinase ABL
Synonyms Abelson murine leukemia viral oncogene homolog 1 | Abelson tyrosine-protein kinase 1 | Abl | Abl1 | Proto-oncogene c-Abl | Tyrosine-protein kinase ABL1 | p150
Organism Mus musculus
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase abl family

Target Components

Component Description Relationship Accession
Tyrosine-protein kinase ABL1 SINGLE PROTEIN P00520

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0001726 (ruffle)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005783 (endoplasmic reticulum)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0015629 (actin cytoskeleton)
GO:0016604 (nuclear body)
GO:0030425 (dendrite)
GO:0030426 (growth cone)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO:0031252 (cell leading edge)
GO:0032991 (macromolecular complex)
GO:0043005 (neuron projection)
GO:0043025 (neuronal cell body)
GO:0045202 (synapse)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0001784 (phosphotyrosine binding)
GO:0003677 (DNA binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005080 (protein kinase C binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008022 (protein C-terminus binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0017124 (SH3 domain binding)
GO:0019901 (protein kinase binding)
GO:0019904 (protein domain specific binding)
GO:0019905 (syntaxin binding)
GO:0030145 (manganese ion binding)
GO:0038191 (neuropilin binding)
GO:0042169 (SH2 domain binding)
GO:0046872 (metal ion binding)
GO:0046875 (ephrin receptor binding)
GO:0051015 (actin filament binding)
GO:0051019 (mitogen-activated protein kinase binding)
GO:0070064 (proline-rich region binding)
GO:0070097 (delta-catenin binding)
GO Biological Process GO:0001843 (neural tube closure)
GO:0001922 (B-1 B cell homeostasis)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0002322 (B cell proliferation involved in immune response)
GO:0002333 (transitional one stage B cell differentiation)
GO:0006281 (DNA repair)
GO:0006468 (protein phosphorylation)
GO:0006897 (endocytosis)
GO:0006909 (phagocytosis)
GO:0006914 (autophagy)
GO:0006915 (apoptotic process)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0006975 (DNA damage induced protein phosphorylation)
GO:0006979 (response to oxidative stress)
GO:0007155 (cell adhesion)
GO:0007173 (epidermal growth factor receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007229 (integrin-mediated signaling pathway)
GO:0009791 (post-embryonic development)
GO:0010595 (positive regulation of endothelial cell migration)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0021587 (cerebellum morphogenesis)
GO:0022408 (negative regulation of cell-cell adhesion)
GO:0030035 (microspike assembly)
GO:0030036 (actin cytoskeleton organization)
GO:0030182 (neuron differentiation)
GO:0030514 (negative regulation of BMP signaling pathway)
GO:0030516 (regulation of axon extension)
GO:0031113 (regulation of microtubule polymerization)
GO:0032489 (regulation of Cdc42 protein signal transduction)
GO:0032956 (regulation of actin cytoskeleton organization)
GO:0033690 (positive regulation of osteoblast proliferation)
GO:0034446 (substrate adhesion-dependent cell spreading)
GO:0035791 (platelet-derived growth factor receptor-beta signaling pathway)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0038189 (neuropilin signaling pathway)
GO:0042100 (B cell proliferation)
GO:0042127 (regulation of cell proliferation)
GO:0042770 (signal transduction in response to DNA damage)
GO:0043065 (positive regulation of apoptotic process)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0043124 (negative regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0043542 (endothelial cell migration)
GO:0045087 (innate immune response)
GO:0045184 (establishment of protein localization)
GO:0045580 (regulation of T cell differentiation)
GO:0045930 (negative regulation of mitotic cell cycle)
GO:0045931 (positive regulation of mitotic cell cycle)
GO:0046632 (alpha-beta T cell differentiation)
GO:0046777 (protein autophosphorylation)
GO:0048008 (platelet-derived growth factor receptor signaling pathway)
GO:0048536 (spleen development)
GO:0048538 (thymus development)
GO:0048668 (collateral sprouting)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0050798 (activated T cell proliferation)
GO:0050853 (B cell receptor signaling pathway)
GO:0050885 (neuromuscular process controlling balance)
GO:0051281 (positive regulation of release of sequestered calcium ion into cytosol)
GO:0051353 (positive regulation of oxidoreductase activity)
GO:0051444 (negative regulation of ubiquitin-protein transferase activity)
GO:0051496 (positive regulation of stress fiber assembly)
GO:0051726 (regulation of cell cycle)
GO:0051894 (positive regulation of focal adhesion assembly)
GO:0060020 (Bergmann glial cell differentiation)
GO:0060563 (neuroepithelial cell differentiation)
GO:0070301 (cellular response to hydrogen peroxide)
GO:0070373 (negative regulation of ERK1 and ERK2 cascade)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0071222 (cellular response to lipopolysaccharide)
GO:0071901 (negative regulation of protein serine/threonine kinase activity)
GO:0072358 (cardiovascular system development)
GO:0090050 (positive regulation of cell migration involved in sprouting angiogenesis)
GO:0090135 (actin filament branching)
GO:1900026 (positive regulation of substrate adhesion-dependent cell spreading)
GO:1900042 (positive regulation of interleukin-2 secretion)
GO:1900272 (negative regulation of long-term synaptic potentiation)
GO:1900275 (negative regulation of phospholipase C activity)
GO:1901216 (positive regulation of neuron death)
GO:1902715 (positive regulation of interferon-gamma secretion)
GO:1903053 (regulation of extracellular matrix organization)
GO:1904528 (positive regulation of microtubule binding)
GO:1904531 (positive regulation of actin filament binding)
GO:1905244 (regulation of modification of synaptic structure)
GO:1905555 (positive regulation blood vessel branching)
GO:1990051 (activation of protein kinase C activity)
GO:2000096 (positive regulation of Wnt signaling pathway, planar cell polarity pathway)
GO:2000251 (positive regulation of actin cytoskeleton reorganization)
GO:2000352 (negative regulation of endothelial cell apoptotic process)
GO:2000772 (regulation of cellular senescence)
GO:2000773 (negative regulation of cellular senescence)
GO:2001020 (regulation of response to DNA damage stimulus)

Target Cross References - Protein

canSAR P00520
IntAct P00520
Reactome R-MMU-2029482 (Regulation of actin dynamics for phagocytic cup formation.)
R-MMU-375170 (CDO in myogenesis.)
R-MMU-428890 (Role of ABL in ROBO-SLIT signaling.)
R-MMU-5663213 (RHO GTPases Activate WASPs and WAVEs.)
R-MMU-5685938 (HDR through Single Strand Annealing (SSA).)
R-MMU-5693565 (Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.)
R-MMU-69231 (Cyclin D associated events in G1.)
UniProt P00520 P97896 Q61252 Q61253 Q61254 Q61255 Q61256 Q61257 Q61258 Q61259 Q61260 Q61261 Q6PCM5 Q8C1X4

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001452 (SH3_domain.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR015015 (F-actin_binding.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR033221 (ABL1.)
IPR035837 (ABL_SH2.)
IPR036028 (SH3-like_dom_sf.)
IPR036860 (SH2_dom_sf.)
Pfam PF00017 (SH2)
PF00018 (SH3_1)
PF07714 (Pkinase_Tyr)
PF08919 (F_actin_bind)

Target Cross References - Structure

PDBe 1ABO 1ABQ 1FPU 1IEP 1M52 1OPJ 1OPK 2HZN 2QOH 2Z60 3DK3 3DK6 3DK7 3IK3 3K5V 3KF4 3KFA 3MS9 3MSS 3OXZ 3OY3 5IH2