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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL309
Target Type SINGLE PROTEIN
Preferred Name Muscarinic acetylcholine receptor M2
Synonyms Chrm-2 | Chrm2 | Muscarinic acetylcholine receptor M2
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > acetylcholine receptor

Target Components

Component Description Relationship Accession
Muscarinic acetylcholine receptor M2 SINGLE PROTEIN P10980

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111433 Muscarinic receptor M1 and M2 SELECTIVITY GROUP
CHEMBL2111347 Muscarinic receptor M2 and M3 SELECTIVITY GROUP
CHEMBL1907609 Muscarinic acetylcholine receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0030425 (dendrite)
GO:0032279 (asymmetric synapse)
GO:0032280 (symmetric synapse)
GO:0043025 (neuronal cell body)
GO:0043679 (axon terminus)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0008144 (drug binding)
GO:0016907 (G-protein coupled acetylcholine receptor activity)
GO Biological Process GO:0006940 (regulation of smooth muscle contraction)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007197 (adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway)
GO:0007207 (phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway)
GO:0007213 (G-protein coupled acetylcholine receptor signaling pathway)
GO:0007271 (synaptic transmission, cholinergic)
GO:0008016 (regulation of heart contraction)
GO:0009615 (response to virus)

Target Cross References - Protein

canSAR P10980
Guide to Pharmacology 14
MICAD NBK23717 (Muscarinic M2 receptor)
Reactome R-RNO-390648 (Muscarinic acetylcholine receptors.)
R-RNO-418594 (G alpha (i) signalling events.)
R-RNO-8856825 (Cargo recognition for clathrin-mediated endocytosis.)
R-RNO-8856828 (Clathrin-mediated endocytosis.)
UniProt P10980 Q9Z2Z1

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000995 (Musac_Ach_rcpt.)
IPR001065 (Musac_Ach_M2_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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