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Target Report Card

Target Name and Classification

Target ID CHEMBL3072
Preferred Name Androgen Receptor
Synonyms Androgen receptor | Ar | Dihydrotestosterone receptor | Nr3c4 | Nuclear receptor subfamily 3 group C member 4
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 3 > nuclear hormone receptor subfamily 3 group c > nuclear hormone receptor subfamily 3 group c member 4

Target Components

Component Description Relationship Accession
Androgen receptor SINGLE PROTEIN P15207

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0000790 (nuclear chromatin)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO Molecular Function GO:0003677 (DNA binding)
GO:0003682 (chromatin binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0004879 (RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding)
GO:0004882 (androgen receptor activity)
GO:0005102 (receptor binding)
GO:0005496 (steroid binding)
GO:0005497 (androgen binding)
GO:0005515 (protein binding)
GO:0008013 (beta-catenin binding)
GO:0008134 (transcription factor binding)
GO:0008270 (zinc ion binding)
GO:0008289 (lipid binding)
GO:0019904 (protein domain specific binding)
GO:0032553 (ribonucleotide binding)
GO:0043565 (sequence-specific DNA binding)
GO:0044212 (transcription regulatory region DNA binding)
GO:0046872 (metal ion binding)
GO:0050681 (androgen receptor binding)
GO Biological Process GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0007283 (spermatogenesis)
GO:0007620 (copulation)
GO:0008049 (male courtship behavior)
GO:0008284 (positive regulation of cell proliferation)
GO:0014734 (skeletal muscle hypertrophy)
GO:0019098 (reproductive behavior)
GO:0030521 (androgen receptor signaling pathway)
GO:0030522 (intracellular receptor signaling pathway)
GO:0032355 (response to estradiol)
GO:0032868 (response to insulin)
GO:0033574 (response to testosterone)
GO:0042327 (positive regulation of phosphorylation)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0045720 (negative regulation of integrin biosynthetic process)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046661 (male sex differentiation)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0060406 (positive regulation of penile erection)
GO:0060736 (prostate gland growth)
GO:0071372 (cellular response to follicle-stimulating hormone stimulus)
GO:0071383 (cellular response to steroid hormone stimulus)
GO:1903076 (regulation of protein localization to plasma membrane)
GO:2001237 (negative regulation of extrinsic apoptotic signaling pathway)

Target Cross References - Protein

canSAR P15207
IntAct P15207
Guide to Pharmacology 628
MICAD NBK22983 (Androgen receptor)
NBK23162 (Androgen receptor)
UniProt P15207 Q63049

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001103 (Andrgn_rcpt.)
IPR001628 (Znf_hrmn_rcpt.)
IPR013088 (Znf_NHR/GATA.)
IPR035500 (NHR_like_dom_sf.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)
PF02166 (Androgen_recep)

Target Cross References - Structure

PDBe 1I37 1I38 1R4I 1XNN 2IHQ 2NW4 3G0W
CREDO 1I37 1I38 1R4I 1XNN 2IHQ 2NW4 3G0W