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Target Report Card

Target Name and Classification

Target ID CHEMBL3071
Target Type SINGLE PROTEIN
Preferred Name Dopamine D1 receptor
Synonyms D(1A) dopamine receptor | Dopamine D1 receptor | Drd1 | Drd1a | Gpcr15
Organism Mus musculus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > dopamine receptor

Target Components

Component Description Relationship Accession
D(1A) dopamine receptor SINGLE PROTEIN Q61616

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111359 Dopamine receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005901 (caveola)
GO:0012505 (endomembrane system)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0043025 (neuronal cell body)
GO:0043197 (dendritic spine)
GO:0043198 (dendritic shaft)
GO:0043679 (axon terminus)
GO:0044326 (dendritic spine neck)
GO:0044327 (dendritic spine head)
GO:0060170 (ciliary membrane)
GO:0097730 (non-motile cilium)
GO Molecular Function GO:0001588 (dopamine neurotransmitter receptor activity, coupled via Gs)
GO:0001965 (G-protein alpha-subunit binding)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004952 (dopamine neurotransmitter receptor activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0008144 (drug binding)
GO:0019903 (protein phosphatase binding)
GO:0031701 (angiotensin receptor binding)
GO:0031750 (D3 dopamine receptor binding)
GO:0035240 (dopamine binding)
GO:0044877 (macromolecular complex binding)
GO:0046982 (protein heterodimerization activity)
GO:0051117 (ATPase binding)
GO Biological Process GO:0001659 (temperature homeostasis)
GO:0001661 (conditioned taste aversion)
GO:0001662 (behavioral fear response)
GO:0001932 (regulation of protein phosphorylation)
GO:0001963 (synaptic transmission, dopaminergic)
GO:0001964 (startle response)
GO:0001975 (response to amphetamine)
GO:0006469 (negative regulation of protein kinase activity)
GO:0006606 (protein import into nucleus)
GO:0006886 (intracellular protein transport)
GO:0006936 (muscle contraction)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007187 (G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007190 (activation of adenylate cyclase activity)
GO:0007191 (adenylate cyclase-activating dopamine receptor signaling pathway)
GO:0007212 (dopamine receptor signaling pathway)
GO:0007612 (learning)
GO:0007613 (memory)
GO:0007617 (mating behavior)
GO:0007625 (grooming behavior)
GO:0007626 (locomotory behavior)
GO:0007628 (adult walking behavior)
GO:0007631 (feeding behavior)
GO:0008306 (associative learning)
GO:0008542 (visual learning)
GO:0010628 (positive regulation of gene expression)
GO:0014002 (astrocyte development)
GO:0015872 (dopamine transport)
GO:0019226 (transmission of nerve impulse)
GO:0019228 (neuronal action potential)
GO:0019229 (regulation of vasoconstriction)
GO:0019722 (calcium-mediated signaling)
GO:0021542 (dentate gyrus development)
GO:0021756 (striatum development)
GO:0021766 (hippocampus development)
GO:0021853 (cerebral cortex GABAergic interneuron migration)
GO:0030335 (positive regulation of cell migration)
GO:0030336 (negative regulation of cell migration)
GO:0030432 (peristalsis)
GO:0031161 (phosphatidylinositol catabolic process)
GO:0035106 (operant conditioning)
GO:0035176 (social behavior)
GO:0042053 (regulation of dopamine metabolic process)
GO:0042220 (response to cocaine)
GO:0042311 (vasodilation)
GO:0042321 (negative regulation of circadian sleep/wake cycle, sleep)
GO:0042493 (response to drug)
GO:0042711 (maternal behavior)
GO:0043269 (regulation of ion transport)
GO:0043987 (histone H3-S10 phosphorylation)
GO:0045762 (positive regulation of adenylate cyclase activity)
GO:0045838 (positive regulation of membrane potential)
GO:0046323 (glucose import)
GO:0046488 (phosphatidylinositol metabolic process)
GO:0046959 (habituation)
GO:0046960 (sensitization)
GO:0048148 (behavioral response to cocaine)
GO:0048169 (regulation of long-term neuronal synaptic plasticity)
GO:0051281 (positive regulation of release of sequestered calcium ion into cytosol)
GO:0051482 (positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway)
GO:0051968 (positive regulation of synaptic transmission, glutamatergic)
GO:0060134 (prepulse inhibition)
GO:0060158 (phospholipase C-activating dopamine receptor signaling pathway)
GO:0060291 (long-term synaptic potentiation)
GO:0060292 (long term synaptic depression)
GO:0071870 (cellular response to catecholamine stimulus)
GO:1900273 (positive regulation of long-term synaptic potentiation)
GO:1903351 (cellular response to dopamine)
GO:2000253 (positive regulation of feeding behavior)

Target Cross References - Protein

canSAR Q61616
MICAD NBK23009 (D1 dopamine receptors)
NBK23252 (Dopamine D1 receptor)
Reactome R-MMU-390651 (Dopamine receptors.)
R-MMU-418555 (G alpha (s) signalling events.)
UniProt B2RPW8 Q61616 Q8C8P8

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000929 (Dopamine_rcpt.)
IPR001413 (Dopamine_D1_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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