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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3068
Target Type SINGLE PROTEIN
Preferred Name Neuronal acetylcholine receptor subunit alpha-3
Synonyms CHRNA3 | NACHRA3 | Neuronal acetylcholine receptor subunit alpha-3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > nicotinic acetylcholine receptor > nicotinic acetylcholine receptor alpha subunit

Target Components

Component Description Relationship Accession
Neuronal acetylcholine receptor subunit alpha-3 SINGLE PROTEIN P32297

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3137273 Nicotinic acetylcholine receptor alpha3/beta4/alpha5 PROTEIN COMPLEX
CHEMBL1907594 Neuronal acetylcholine receptor; alpha3/beta4 PROTEIN COMPLEX
CHEMBL3137272 Nicotinic acetylcholine receptor alpha3/beta2/alpha5 PROTEIN COMPLEX
CHEMBL3885595 Integrin alpha-5/Neuronal acetylcholine receptor subunit alpha-3/Neuronal acetylcholine receptor subunit beta-2/Neuronal acetylcholine receptor subunit beta-4 PROTEIN COMPLEX
CHEMBL2111384 Nicotinic acetylcholine receptor alpha3/betaX PROTEIN COMPLEX GROUP
CHEMBL2221346 Neuronal acetylcholine receptors; alpha-3/beta-4, alpha-5, beta-2 PROTEIN COMPLEX GROUP
CHEMBL3137285 Nicotinic acetylcholine receptor alpha6/alpha3/beta4 PROTEIN COMPLEX
CHEMBL2109234 Neuronal acetylcholine receptor; alpha3/beta2 PROTEIN COMPLEX
CHEMBL2109233 Neuronal acetylcholine receptor; alpha3/alpha6/beta2/beta3 PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000080644
Ensembl ENSG00000080644
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005892 (acetylcholine-gated channel complex)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0030425 (dendrite)
GO:0043025 (neuronal cell body)
GO:0044853 (plasma membrane raft)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004888 (transmembrane signaling receptor activity)
GO:0005216 (ion channel activity)
GO:0005230 (extracellular ligand-gated ion channel activity)
GO:0005515 (protein binding)
GO:0015276 (ligand-gated ion channel activity)
GO:0015464 (acetylcholine receptor activity)
GO:0022848 (acetylcholine-gated cation channel activity)
GO:0022850 (serotonin-gated cation channel activity)
GO:0042166 (acetylcholine binding)
GO Biological Process GO:0006811 (ion transport)
GO:0006940 (regulation of smooth muscle contraction)
GO:0007165 (signal transduction)
GO:0007171 (activation of transmembrane receptor protein tyrosine kinase activity)
GO:0007271 (synaptic transmission, cholinergic)
GO:0007399 (nervous system development)
GO:0007626 (locomotory behavior)
GO:0014056 (regulation of acetylcholine secretion, neurotransmission)
GO:0034220 (ion transmembrane transport)
GO:0035095 (behavioral response to nicotine)
GO:0042391 (regulation of membrane potential)
GO:0048814 (regulation of dendrite morphogenesis)
GO:0060079 (excitatory postsynaptic potential)
GO:0060084 (synaptic transmission involved in micturition)
GO:0095500 (acetylcholine receptor signaling pathway)
GO:0098655 (cation transmembrane transport)
GO:1905144 (response to acetylcholine)
Wikipedia CHRNA3

Target Cross References - Protein

canSAR P32297
Human Protein Atlas ENSG00000080644
IntAct P32297
Guide to Pharmacology 464
Open Targets ENSG00000080644
PharmGKB PA113
Pharos P32297 (Tclin)
Reactome R-HSA-629587 (Highly sodium permeable acetylcholine nicotinic receptors.)
R-HSA-629594 (Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.)
R-HSA-629597 (Highly calcium permeable nicotinic acetylcholine receptors.)
UniProt P32297 Q15823 Q4KMN8 Q86U77 Q96RH3 Q99553 Q9BQ93 Q9BRR4

Target Cross References - Domain

InterPro IPR002394 (Nicotinic_acetylcholine_rcpt.)
IPR006029 (Neurotrans-gated_channel_TM.)
IPR006201 (Neur_channel.)
IPR006202 (Neur_chan_lig-bd.)
IPR018000 (Neurotransmitter_ion_chnl_CS.)
IPR036719 (Neuro-gated_channel_TM_sf.)
IPR036734 (Neur_chan_lig-bd_sf.)
Pfam PF02931 (Neur_chan_LBD)
PF02932 (Neur_chan_memb)

Target Cross References - Structure

PDBe 4ZK4 5SYO 5TVC
CREDO 4ZK4 5SYO 5TVC
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