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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3066
Target Type SINGLE PROTEIN
Preferred Name Gonadotropin-releasing hormone receptor
Synonyms GnRH receptor | GnRH-R | Gnrhr | Gonadotropin-releasing hormone receptor
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > gnrh receptor

Target Components

Component Description Relationship Accession
Gonadotropin-releasing hormone receptor SINGLE PROTEIN P30969

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004968 (gonadotropin-releasing hormone receptor activity)
GO:0005515 (protein binding)
GO:0016500 (protein-hormone receptor activity)
GO:0016520 (growth hormone-releasing hormone receptor activity)
GO:0042277 (peptide binding)
GO Biological Process GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007623 (circadian rhythm)
GO:0008285 (negative regulation of cell proliferation)
GO:0097211 (cellular response to gonadotropin-releasing hormone)

Target Cross References - Protein

canSAR P30969
Guide to Pharmacology 256
UniProt P30969

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR001658 (GphnRH_fam_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
IPR027982 (GphnRH_rcpt.)
Pfam PF00001 (7tm_1)
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