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Target Report Card

Target Name and Classification

Target ID CHEMBL3056
Target Type SINGLE PROTEIN
Preferred Name Androgen Receptor
Synonyms Androgen receptor | Ar | Dihydrotestosterone receptor | Nr3c4 | Nuclear receptor subfamily 3 group C member 4
Organism Mus musculus
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 3 > nuclear hormone receptor subfamily 3 group c > nuclear hormone receptor subfamily 3 group c member 4

Target Components

Component Description Relationship Accession
Androgen receptor SINGLE PROTEIN P19091

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0000790 (nuclear chromatin)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0043234 (protein complex)
GO Molecular Function GO:0000978 (RNA polymerase II core promoter proximal region sequence-specific DNA binding)
GO:0001077 (transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0001085 (RNA polymerase II transcription factor binding)
GO:0003677 (DNA binding)
GO:0003682 (chromatin binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0004879 (RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding)
GO:0004882 (androgen receptor activity)
GO:0005102 (receptor binding)
GO:0005496 (steroid binding)
GO:0005497 (androgen binding)
GO:0005515 (protein binding)
GO:0008013 (beta-catenin binding)
GO:0008134 (transcription factor binding)
GO:0008270 (zinc ion binding)
GO:0008289 (lipid binding)
GO:0019899 (enzyme binding)
GO:0043565 (sequence-specific DNA binding)
GO:0044212 (transcription regulatory region DNA binding)
GO:0046872 (metal ion binding)
GO:0051117 (ATPase binding)
GO:0070974 (POU domain binding)
GO Biological Process GO:0001701 (in utero embryonic development)
GO:0003073 (regulation of systemic arterial blood pressure)
GO:0003382 (epithelial cell morphogenesis)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0007283 (spermatogenesis)
GO:0007338 (single fertilization)
GO:0008284 (positive regulation of cell proliferation)
GO:0008285 (negative regulation of cell proliferation)
GO:0008584 (male gonad development)
GO:0009566 (fertilization)
GO:0009987 (cellular process)
GO:0010468 (regulation of gene expression)
GO:0010628 (positive regulation of gene expression)
GO:0019102 (male somatic sex determination)
GO:0030521 (androgen receptor signaling pathway)
GO:0030522 (intracellular receptor signaling pathway)
GO:0033148 (positive regulation of intracellular estrogen receptor signaling pathway)
GO:0033327 (Leydig cell differentiation)
GO:0035264 (multicellular organism growth)
GO:0042327 (positive regulation of phosphorylation)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0043410 (positive regulation of MAPK cascade)
GO:0043568 (positive regulation of insulin-like growth factor receptor signaling pathway)
GO:0045597 (positive regulation of cell differentiation)
GO:0045720 (negative regulation of integrin biosynthetic process)
GO:0045726 (positive regulation of integrin biosynthetic process)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0045945 (positive regulation of transcription from RNA polymerase III promoter)
GO:0048608 (reproductive structure development)
GO:0048638 (regulation of developmental growth)
GO:0048645 (organ formation)
GO:0048808 (male genitalia morphogenesis)
GO:0050680 (negative regulation of epithelial cell proliferation)
GO:0050790 (regulation of catalytic activity)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0051259 (protein oligomerization)
GO:0060520 (activation of prostate induction by androgen receptor signaling pathway)
GO:0060571 (morphogenesis of an epithelial fold)
GO:0060599 (lateral sprouting involved in mammary gland duct morphogenesis)
GO:0060685 (regulation of prostatic bud formation)
GO:0060736 (prostate gland growth)
GO:0060740 (prostate gland epithelium morphogenesis)
GO:0060742 (epithelial cell differentiation involved in prostate gland development)
GO:0060748 (tertiary branching involved in mammary gland duct morphogenesis)
GO:0060749 (mammary gland alveolus development)
GO:0061458 (reproductive system development)
GO:0072520 (seminiferous tubule development)
GO:0090003 (regulation of establishment of protein localization to plasma membrane)
GO:2001237 (negative regulation of extrinsic apoptotic signaling pathway)

Target Cross References - Protein

canSAR P19091
IntAct P19091
MICAD NBK22983 (Androgen receptor)
NBK23162 (Androgen receptor)
Reactome R-MMU-383280 (Nuclear Receptor transcription pathway.)
R-MMU-5625886 (Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.)
R-MMU-5689880 (Ub-specific processing proteases.)
UniProt P19091

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001103 (Andrgn_rcpt.)
IPR001628 (Znf_hrmn_rcpt.)
IPR013088 (Znf_NHR/GATA.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)
PF02166 (Androgen_recep)

Target Cross References - Structure

PDBe 2QPY
CREDO 2QPY
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