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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL304
Target Type SINGLE PROTEIN
Preferred Name Norepinephrine transporter
Synonyms Slc6a2 | Transporter
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc06 neurotransmitter transporter family

Target Components

Component Description Relationship Accession
Transporter SINGLE PROTEIN Q9WTR4

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095175 Monoamine transporters; Norepininephrine & dopamine SELECTIVITY GROUP
CHEMBL2096672 Monoamine transporters; Norepinephrine & serotonin SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043005 (neuron projection)
GO:0045121 (membrane raft)
GO Molecular Function GO:0005328 (neurotransmitter:sodium symporter activity)
GO:0005333 (norepinephrine transmembrane transporter activity)
GO:0005515 (protein binding)
GO:0015293 (symporter activity)
GO:0043014 (alpha-tubulin binding)
GO:0048487 (beta-tubulin binding)
GO Biological Process GO:0006836 (neurotransmitter transport)
GO:0015874 (norepinephrine transport)
GO:0042493 (response to drug)
GO:0055085 (transmembrane transport)

Target Cross References - Protein

canSAR Q9WTR4
MICAD NBK22978 (Brain norepinephrine transporter (NET))
NBK23167 (Norepinephrine transporter (NET))
NBK23205 (Brain norepinephrine transporter (NET))
NBK23527 (Brain norepinephrine transporter (NET))
UniProt Q9WTR4

Target Cross References - Domain

InterPro IPR000175 (Na/ntran_symport.)
IPR002435 (Na/ntran_symport_noradrenaline.)
IPR037272 (SNS_sf.)
Pfam PF00209 (SNF)
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