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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL303
Target Type SINGLE PROTEIN
Preferred Name Glutamate [NMDA] receptor subunit epsilon 4
Synonyms GluN2D | GluN2D | Glutamate [NMDA] receptor subunit epsilon-4 | Glutamate receptor ionotropic, NMDA 2D | Grin2d | N-methyl D-aspartate receptor subtype 2D | NMDAR2D | NR2D
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > ionotropic glutamate receptor > nmda receptor

Target Components

Component Description Relationship Accession
Glutamate receptor ionotropic, NMDA 2D SINGLE PROTEIN Q62645

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096669 Glutamate receptors; NMDA/AMPA PROTEIN COMPLEX GROUP
CHEMBL3038506 Ionotropic glutamate receptor NMDA 1/2D PROTEIN COMPLEX
CHEMBL1907608 Glutamate NMDA receptor PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0008328 (ionotropic glutamate receptor complex)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0017146 (NMDA selective glutamate receptor complex)
GO:0030054 (cell junction)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004970 (ionotropic glutamate receptor activity)
GO:0004972 (NMDA glutamate receptor activity)
GO:0005216 (ion channel activity)
GO:0005234 (extracellular-glutamate-gated ion channel activity)
GO:0005261 (cation channel activity)
GO:0005515 (protein binding)
GO:0016595 (glutamate binding)
GO:0022843 (voltage-gated cation channel activity)
GO:0022849 (glutamate-gated calcium ion channel activity)
GO:0038023 (signaling receptor activity)
GO:0042165 (neurotransmitter binding)
GO Biological Process GO:0006811 (ion transport)
GO:0007165 (signal transduction)
GO:0019722 (calcium-mediated signaling)
GO:0035235 (ionotropic glutamate receptor signaling pathway)
GO:0035249 (synaptic transmission, glutamatergic)
GO:0060079 (excitatory postsynaptic potential)
GO:0097553 (calcium ion transmembrane import into cytosol)

Target Cross References - Protein

canSAR Q62645
IntAct Q62645
Guide to Pharmacology 459
Reactome R-RNO-438066 (Unblocking of NMDA receptor, glutamate binding and activation.)
R-RNO-442729 (CREB phosphorylation through the activation of CaMKII.)
R-RNO-442982 (Ras activation upon Ca2+ influx through NMDA receptor.)
R-RNO-5673001 (RAF/MAP kinase cascade.)
R-RNO-8849932 (Synaptic adhesion-like molecules.)
UniProt Q62645 Q63381 Q63382 Q63729 Q63730

Target Cross References - Domain

InterPro IPR001320 (Iontro_rcpt.)
IPR001508 (Iono_rcpt_met.)
IPR001828 (ANF_lig-bd_rcpt.)
IPR019594 (Glu/Gly-bd.)
IPR028082 (Peripla_BP_I.)
Pfam PF00060 (Lig_chan)
PF01094 (ANF_receptor)
PF10613 (Lig_chan-Glu_bd)

Target Cross References - Structure

PDBe 3OEK 3OEL 3OEM 3OEN 4JWY
CREDO 3OEK 3OEL 3OEM 3OEN 4JWY
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