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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3026
Preferred Name GABA receptor alpha-3 subunit
Synonyms GABA(A) receptor subunit alpha-3 | GABRA3 | Gamma-aminobutyric acid receptor subunit alpha-3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > gaba-a receptor

Target Components

Component Description Relationship Accession
Gamma-aminobutyric acid receptor subunit alpha-3 SINGLE PROTEIN P34903

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2093872 GABA-A receptor; anion channel PROTEIN COMPLEX GROUP
CHEMBL2109244 GABA-A receptor; agonist GABA site PROTEIN COMPLEX GROUP
CHEMBL2109243 GABA-A receptor; benzodiazepine site PROTEIN COMPLEX GROUP
CHEMBL3885573 Gamma-aminobutyric acid receptor subunit alpha-3/ beta-3/gamma-3 PROTEIN COMPLEX
CHEMBL3885572 Gamma-aminobutyric acid receptor subunit alpha-3/ beta-2 PROTEIN COMPLEX
CHEMBL3885575 Gamma-aminobutyric acid receptor subunit alpha-3/beta-3/theta PROTEIN COMPLEX
CHEMBL2094120 GABA-A receptor; alpha-3/beta-3/gamma-2 PROTEIN COMPLEX
CHEMBL3885574 Gamma-aminobutyric acid receptor subunit alpha-3/beta-3 PROTEIN COMPLEX
CHEMBL2111339 GABA A receptor alpha-3/beta-2/gamma-2 PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1783282 AZD7325 GABA receptor alpha-3 subunit positive allosteric modulator 2 Other PubMed PubMed
CHEMBL1783256 AZD6280 GABA receptor alpha-3 subunit positive allosteric modulator 1 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000011677
Ensembl ENSG00000011677
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0034707 (chloride channel complex)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO:1902711 (GABA-A receptor complex)
GO Molecular Function GO:0004888 (transmembrane signaling receptor activity)
GO:0004890 (GABA-A receptor activity)
GO:0005216 (ion channel activity)
GO:0005230 (extracellular ligand-gated ion channel activity)
GO:0005254 (chloride channel activity)
GO:0005515 (protein binding)
GO:0008503 (benzodiazepine receptor activity)
GO Biological Process GO:0006811 (ion transport)
GO:0006821 (chloride transport)
GO:0007214 (gamma-aminobutyric acid signaling pathway)
GO:0034220 (ion transmembrane transport)
GO:1902476 (chloride transmembrane transport)
Wikipedia GABRA3

Target Cross References - Protein

canSAR P34903
Human Protein Atlas ENSG00000011677
IntAct P34903
Guide to Pharmacology 406
Open Targets ENSG00000011677
PharmGKB PA28491
Pharos P34903 (Tclin)
Reactome R-HSA-112314 (Neurotransmitter receptors and postsynaptic signal transmission.)
R-HSA-977441 (GABA A receptor activation.)
UniProt P34903 Q8TAF9

Target Cross References - Domain

InterPro IPR001390 (GABAAa_rcpt.)
IPR005433 (GABBAa3_rcpt.)
IPR006028 (GABAA/Glycine_rcpt.)
IPR006029 (Neurotrans-gated_channel_TM.)
IPR006201 (Neur_channel.)
IPR006202 (Neur_chan_lig-bd.)
IPR018000 (Neurotransmitter_ion_chnl_CS.)
IPR036719 (Neuro-gated_channel_TM_sf.)
IPR036734 (Neur_chan_lig-bd_sf.)
Pfam PF02931 (Neur_chan_LBD)
PF02932 (Neur_chan_memb)