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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3025
Target Type SINGLE PROTEIN
Preferred Name Carbonic anhydrase VI
Synonyms CA-VI | CA6 | Carbonate dehydratase VI | Carbonic anhydrase 6 | Carbonic anhydrase VI | Salivary carbonic anhydrase | Secreted carbonic anhydrase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > lyase

Target Components

Component Description Relationship Accession
Carbonic anhydrase 6 SINGLE PROTEIN P23280

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095180 Carbonic anhydrase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000131686
Ensembl ENSG00000131686
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004089 (carbonate dehydratase activity)
GO:0008270 (zinc ion binding)
GO:0016829 (lyase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001580 (detection of chemical stimulus involved in sensory perception of bitter taste)
GO:0006730 (one-carbon metabolic process)
GO:0015701 (bicarbonate transport)
Wikipedia Carbonic_anhydrase_VI

Target Cross References - Protein

canSAR P23280
Human Protein Atlas ENSG00000131686
Open Targets ENSG00000131686
PharmGKB PA25995
Reactome R-HSA-1475029 (Reversible hydration of carbon dioxide.)
UniProt E7EMQ1 P23280 Q5FBW3 Q5FC00 Q96QX8 Q9UF03

Target Cross References - Domain

InterPro IPR001148 (Carbonic_anhydrase_a.)
IPR018338 (Carbonic_anhydrase_a-class_CS.)
IPR018428 (Carbonic_anhydrase_CA6.)
IPR023561 (Carbonic_anhydrase_a-class.)
Pfam PF00194 (Carb_anhydrase)

Target Cross References - Structure

PDBe 3FE4
CREDO 3FE4
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