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Target Report Card

Target Name and Classification

Target ID CHEMBL302
Preferred Name Adenosine A2a receptor
Synonyms Adenosine receptor A2a | Adora2a
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > nucleotide-like receptor (family a gpcr) > adenosine receptor

Target Components

Component Description Relationship Accession
Adenosine receptor A2a SINGLE PROTEIN P30543

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111386 Adenosine receptor PROTEIN FAMILY
CHEMBL2094131 Adenosine receptors; A1 & A2 SELECTIVITY GROUP
CHEMBL2094117 Adenosine A2 receptor PROTEIN FAMILY
CHEMBL2111403 Adenosine receptor A2a and A3 SELECTIVITY GROUP
CHEMBL2095218 Adenosine receptors; A1 & A2a SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0000139 (Golgi membrane)
GO:0005882 (intermediate filament)
GO:0005886 (plasma membrane)
GO:0012505 (endomembrane system)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0030673 (axolemma)
GO:0032279 (asymmetric synapse)
GO:0042734 (presynaptic membrane)
GO:0043025 (neuronal cell body)
GO:0045211 (postsynaptic membrane)
GO:0048786 (presynaptic active zone)
GO Molecular Function GO:0001609 (G-protein coupled adenosine receptor activity)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0005515 (protein binding)
GO:0031802 (type 5 metabotropic glutamate receptor binding)
GO:0046982 (protein heterodimerization activity)
GO:0051393 (alpha-actinin binding)
GO Biological Process GO:0001963 (synaptic transmission, dopaminergic)
GO:0001973 (adenosine receptor signaling pathway)
GO:0001975 (response to amphetamine)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006469 (negative regulation of protein kinase activity)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007190 (activation of adenylate cyclase activity)
GO:0007205 (protein kinase C-activating G-protein coupled receptor signaling pathway)
GO:0007271 (synaptic transmission, cholinergic)
GO:0007626 (locomotory behavior)
GO:0008285 (negative regulation of cell proliferation)
GO:0014049 (positive regulation of glutamate secretion)
GO:0014057 (positive regulation of acetylcholine secretion, neurotransmission)
GO:0014061 (regulation of norepinephrine secretion)
GO:0030819 (positive regulation of cAMP biosynthetic process)
GO:0031000 (response to caffeine)
GO:0032230 (positive regulation of synaptic transmission, GABAergic)
GO:0035249 (synaptic transmission, glutamatergic)
GO:0035810 (positive regulation of urine volume)
GO:0035815 (positive regulation of renal sodium excretion)
GO:0040013 (negative regulation of locomotion)
GO:0042311 (vasodilation)
GO:0042493 (response to drug)
GO:0042755 (eating behavior)
GO:0043116 (negative regulation of vascular permeability)
GO:0043154 (negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0043279 (response to alkaloid)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0045938 (positive regulation of circadian sleep/wake cycle, sleep)
GO:0046636 (negative regulation of alpha-beta T cell activation)
GO:0048143 (astrocyte activation)
GO:0048167 (regulation of synaptic plasticity)
GO:0048812 (neuron projection morphogenesis)
GO:0050714 (positive regulation of protein secretion)
GO:0050728 (negative regulation of inflammatory response)
GO:0051881 (regulation of mitochondrial membrane potential)
GO:0051899 (membrane depolarization)
GO:0051924 (regulation of calcium ion transport)
GO:0051968 (positive regulation of synaptic transmission, glutamatergic)
GO:0060079 (excitatory postsynaptic potential)
GO:0060080 (inhibitory postsynaptic potential)
GO:0060134 (prepulse inhibition)
GO:2001235 (positive regulation of apoptotic signaling pathway)

Target Cross References - Protein

canSAR P30543
IntAct P30543
Guide to Pharmacology 19
MICAD NBK22976 (Adenosine A2A receptor)
NBK23199 (Adenosine A2A receptor)
NBK23449 (Adenosine A2A receptor)
Reactome R-RNO-187024 (NGF-independant TRKA activation.)
R-RNO-417973 (Adenosine P1 receptors.)
R-RNO-418555 (G alpha (s) signalling events.)
R-RNO-5683826 (Surfactant metabolism.)
UniProt P30543

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR001513 (Adeno_A2A_rcpt.)
IPR001634 (Adenosn_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)