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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3004
Target Type SINGLE PROTEIN
Preferred Name Multidrug resistance-associated protein 1
Synonyms ABCC1 | ATP-binding cassette sub-family C member 1 | LTC4 transporter | Leukotriene C(4) transporter | MRP | MRP1 | Multidrug resistance-associated protein 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > primary active transporter > atp-binding cassette > abcc subfamily

Target Components

Component Description Relationship Accession
Multidrug resistance-associated protein 1 SINGLE PROTEIN P33527

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3430875 Multidrug resistance protein 1/Multidrug resistance associated protein 1 SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000103222 ENSG00000278183
Ensembl ENSG00000103222 ENSG00000278183
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004012 (phospholipid-translocating ATPase activity)
GO:0005215 (transporter activity)
GO:0005524 (ATP binding)
GO:0008559 (xenobiotic-transporting ATPase activity)
GO:0015420 (cobalamin-transporting ATPase activity)
GO:0015431 (glutathione S-conjugate-exporting ATPase activity)
GO:0016787 (hydrolase activity)
GO:0016887 (ATPase activity)
GO:0022857 (transmembrane transporter activity)
GO:0034634 (glutathione transmembrane transporter activity)
GO:0042626 (ATPase activity, coupled to transmembrane movement of substances)
GO:0043225 (anion transmembrane-transporting ATPase activity)
GO:0046623 (sphingolipid-translocating ATPase activity)
GO Biological Process GO:0006691 (leukotriene metabolic process)
GO:0006855 (drug transmembrane transport)
GO:0009235 (cobalamin metabolic process)
GO:0015889 (cobalamin transport)
GO:0034775 (glutathione transmembrane transport)
GO:0042493 (response to drug)
GO:0042908 (xenobiotic transport)
GO:0045332 (phospholipid translocation)
GO:0055085 (transmembrane transport)
GO:0060326 (cell chemotaxis)
GO:0099039 (sphingolipid translocation)
GO:0099133 (ATP hydrolysis coupled anion transmembrane transport)
Wikipedia ABCC1

Target Cross References - Protein

Human Protein Atlas ENSG00000103222 ENSG00000278183
IntAct P33527
Guide to Pharmacology 779
Open Targets ENSG00000103222 ENSG00000278183
PharmGKB PA244
Reactome R-HSA-196741 (Cobalamin (Cbl, vitamin B12) transport and metabolism.)
R-HSA-2142691 (Synthesis of Leukotrienes (LT) and Eoxins (EX).)
R-HSA-382556 (ABC-family proteins mediated transport.)
UniProt A3RJX2 C9JPJ4 O14819 O43333 P33527 P78419 Q59GI9 Q9UQ97 Q9UQ99 Q9UQA0

Target Cross References - Domain

InterPro IPR003439 (ABC_transporter-like.)
IPR003593 (AAA+_ATPase.)
IPR005292 (Multidrug-R_assoc.)
IPR011527 (ABC1_TM_dom.)
IPR017871 (ABC_transporter_CS.)
IPR027417 (P-loop_NTPase.)
IPR036640 (ABC1_TM_sf.)
Pfam PF00005 (ABC_tran)
PF00664 (ABC_membrane)

Target Cross References - Structure

PDBe 2CBZ 4C3Z
CREDO 2CBZ 4C3Z
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