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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL300
Target Type SINGLE PROTEIN
Preferred Name GABA receptor alpha-5 subunit
Synonyms GABA(A) receptor subunit alpha-5 | Gabra-5 | Gabra5 | Gamma-aminobutyric acid receptor subunit alpha-5
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > gaba-a receptor

Target Components

Component Description Relationship Accession
Gamma-aminobutyric acid receptor subunit alpha-5 SINGLE PROTEIN P19969

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096683 Benzodiazepine receptors; peripheral & central SELECTIVITY GROUP
CHEMBL2111374 GABA A receptor alpha-5/beta-3/gamma-2 PROTEIN COMPLEX
CHEMBL1907607 GABA-A receptor; anion channel PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0030425 (dendrite)
GO:0032590 (dendrite membrane)
GO:0032809 (neuronal cell body membrane)
GO:0034707 (chloride channel complex)
GO:0043005 (neuron projection)
GO:0043235 (receptor complex)
GO:0044297 (cell body)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO:0098794 (postsynapse)
GO:0098982 (GABA-ergic synapse)
GO:0099055 (integral component of postsynaptic membrane)
GO:0099056 (integral component of presynaptic membrane)
GO:0099060 (integral component of postsynaptic specialization membrane)
GO:1902711 (GABA-A receptor complex)
GO Molecular Function GO:0004888 (transmembrane signaling receptor activity)
GO:0004890 (GABA-A receptor activity)
GO:0005216 (ion channel activity)
GO:0005230 (extracellular ligand-gated ion channel activity)
GO:0005237 (inhibitory extracellular ligand-gated ion channel activity)
GO:0005254 (chloride channel activity)
GO:0008503 (benzodiazepine receptor activity)
GO:0022851 (GABA-gated chloride ion channel activity)
GO:0050811 (GABA receptor binding)
GO:1904315 (transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)
GO Biological Process GO:0001662 (behavioral fear response)
GO:0006811 (ion transport)
GO:0006821 (chloride transport)
GO:0007165 (signal transduction)
GO:0007214 (gamma-aminobutyric acid signaling pathway)
GO:0007268 (chemical synaptic transmission)
GO:0007420 (brain development)
GO:0007605 (sensory perception of sound)
GO:0008306 (associative learning)
GO:0034220 (ion transmembrane transport)
GO:0042391 (regulation of membrane potential)
GO:0043523 (regulation of neuron apoptotic process)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0048666 (neuron development)
GO:0050877 (nervous system process)
GO:0051932 (synaptic transmission, GABAergic)
GO:0060078 (regulation of postsynaptic membrane potential)
GO:0060119 (inner ear receptor cell development)
GO:0060384 (innervation)
GO:0090102 (cochlea development)
GO:1902476 (chloride transmembrane transport)

Target Cross References - Protein

canSAR P19969
IntAct P19969
Guide to Pharmacology 408
Reactome R-RNO-977441 (GABA A receptor activation.)
UniProt P19969

Target Cross References - Domain

InterPro IPR001390 (GABAAa_rcpt.)
IPR005435 (GABBAa5_rcpt.)
IPR006028 (GABAA/Glycine_rcpt.)
IPR006029 (Neurotrans-gated_channel_TM.)
IPR006201 (Neur_channel.)
IPR006202 (Neur_chan_lig-bd.)
IPR018000 (Neurotransmitter_ion_chnl_CS.)
IPR036719 (Neuro-gated_channel_TM_sf.)
IPR036734 (Neur_chan_lig-bd_sf.)
Pfam PF02931 (Neur_chan_LBD)
PF02932 (Neur_chan_memb)
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