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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2997
Target Type SINGLE PROTEIN
Preferred Name AMP deaminase 2
Synonyms AMP deaminase 2 | AMP deaminase isoform L | AMPD2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
AMP deaminase 2 SINGLE PROTEIN Q01433

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000116337
Ensembl ENSG00000116337
GO Cellular Component GO:0005575 (cellular_component)
GO:0005829 (cytosol)
GO Molecular Function GO:0003876 (AMP deaminase activity)
GO:0005515 (protein binding)
GO:0016787 (hydrolase activity)
GO:0019239 (deaminase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006188 (IMP biosynthetic process)
GO:0009117 (nucleotide metabolic process)
GO:0009168 (purine ribonucleoside monophosphate biosynthetic process)
GO:0032264 (IMP salvage)
GO:0043101 (purine-containing compound salvage)
GO:0046033 (AMP metabolic process)
GO:0046034 (ATP metabolic process)
GO:0046039 (GTP metabolic process)
GO:0052652 (cyclic purine nucleotide metabolic process)
GO:0097009 (energy homeostasis)
Wikipedia AMPD2

Target Cross References - Protein

canSAR Q01433
Human Protein Atlas ENSG00000116337
IntAct Q01433
Open Targets ENSG00000116337
PharmGKB PA24777
Reactome R-HSA-74217 (Purine salvage.)
UniProt B4DK50 B4DZI5 E9PNG0 Q01433 Q14856 Q14857 Q16686 Q16687 Q16688 Q16729 Q5T693 Q5T695 Q96IA1 Q9UDX8 Q9UDX9 Q9UMU4

Target Cross References - Domain

InterPro IPR001365 (A/AMP_deaminase_dom.)
IPR006329 (AMPD.)
IPR006650 (A/AMP_deam_AS.)
IPR029749 (AMPD2.)
IPR032466 (Metal_Hydrolase.)
Pfam PF00962 (A_deaminase)

Target Cross References - Structure

PDBe 4NO3 4NO5
CREDO 4NO3 4NO5
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