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Target Report Card

Target Name and Classification

Target ID CHEMBL2994
Preferred Name Angiotensin-converting enzyme
Synonyms ACE | Ace | Angiotensin-converting enzyme | Angiotensin-converting enzyme, soluble form | CD_antigen=CD143 | Dcp1 | Dipeptidyl carboxypeptidase I | Kininase II
Organism Mus musculus
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mae clan > metallo protease m2 family

Target Components

Component Description Relationship Accession
Angiotensin-converting enzyme SINGLE PROTEIN P09470

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005737 (cytoplasm)
GO:0005764 (lysosome)
GO:0005768 (endosome)
GO:0005886 (plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0009925 (basal plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031526 (brush border membrane)
GO:0031982 (vesicle)
GO:0070062 (extracellular exosome)
GO:0097225 (sperm midpiece)
GO Molecular Function GO:0003779 (actin binding)
GO:0004175 (endopeptidase activity)
GO:0004180 (carboxypeptidase activity)
GO:0005515 (protein binding)
GO:0008144 (drug binding)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0008238 (exopeptidase activity)
GO:0008240 (tripeptidyl-peptidase activity)
GO:0008241 (peptidyl-dipeptidase activity)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0031404 (chloride ion binding)
GO:0031434 (mitogen-activated protein kinase kinase binding)
GO:0031711 (bradykinin receptor binding)
GO:0046872 (metal ion binding)
GO:0051019 (mitogen-activated protein kinase binding)
GO:0070573 (metallodipeptidase activity)
GO Biological Process GO:0001822 (kidney development)
GO:0002446 (neutrophil mediated immunity)
GO:0003081 (regulation of systemic arterial blood pressure by renin-angiotensin)
GO:0003084 (positive regulation of systemic arterial blood pressure)
GO:0006508 (proteolysis)
GO:0006518 (peptide metabolic process)
GO:0007283 (spermatogenesis)
GO:0008217 (regulation of blood pressure)
GO:0009792 (embryo development ending in birth or egg hatching)
GO:0010608 (posttranscriptional regulation of gene expression)
GO:0010629 (negative regulation of gene expression)
GO:0010815 (bradykinin catabolic process)
GO:0014910 (regulation of smooth muscle cell migration)
GO:0019233 (sensory perception of pain)
GO:0031100 (organ regeneration)
GO:0032091 (negative regulation of protein binding)
GO:0032092 (positive regulation of protein binding)
GO:0032496 (response to lipopolysaccharide)
GO:0035814 (negative regulation of renal sodium excretion)
GO:0042310 (vasoconstriction)
GO:0042447 (hormone catabolic process)
GO:0042755 (eating behavior)
GO:0043065 (positive regulation of apoptotic process)
GO:0043171 (peptide catabolic process)
GO:0045777 (positive regulation of blood pressure)
GO:0046325 (negative regulation of glucose import)
GO:0048286 (lung alveolus development)
GO:0050435 (beta-amyloid metabolic process)
GO:0050482 (arachidonic acid secretion)
GO:0050729 (positive regulation of inflammatory response)
GO:0050769 (positive regulation of neurogenesis)
GO:0060047 (heart contraction)
GO:0060177 (regulation of angiotensin metabolic process)
GO:0060978 (angiogenesis involved in coronary vascular morphogenesis)
GO:0061098 (positive regulation of protein tyrosine kinase activity)
GO:0071838 (cell proliferation in bone marrow)
GO:0090281 (negative regulation of calcium ion import)
GO:0097756 (negative regulation of blood vessel diameter)
GO:1900086 (positive regulation of peptidyl-tyrosine autophosphorylation)
GO:1902033 (regulation of hematopoietic stem cell proliferation)
GO:1903597 (negative regulation of gap junction assembly)
GO:2000170 (positive regulation of peptidyl-cysteine S-nitrosylation)

Target Cross References - Protein

canSAR P09470
IntAct P09470
Reactome R-MMU-2022377 (Metabolism of Angiotensinogen to Angiotensins.)
UniProt P09470 P22967 Q6GTS2

Target Cross References - Domain

InterPro IPR001548 (Peptidase_M2.)
Pfam PF01401 (Peptidase_M2)