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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2990
Target Type SINGLE PROTEIN
Preferred Name Alcohol dehydrogenase class II
Synonyms ADH4 | Alcohol dehydrogenase 4 | Alcohol dehydrogenase class II pi chain
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Alcohol dehydrogenase 4 SINGLE PROTEIN P08319

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096668 Alcohol dehydrogenase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000198099
Ensembl ENSG00000198099
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0003960 (NADPH:quinone reductase activity)
GO:0004022 (alcohol dehydrogenase (NAD) activity)
GO:0004024 (alcohol dehydrogenase activity, zinc-dependent)
GO:0004032 (alditol:NADP+ 1-oxidoreductase activity)
GO:0004745 (retinol dehydrogenase activity)
GO:0005503 (all-trans retinal binding)
GO:0008270 (zinc ion binding)
GO:0016491 (oxidoreductase activity)
GO:0016620 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor)
GO:0019115 (benzaldehyde dehydrogenase activity)
GO:0019841 (retinol binding)
GO:0035276 (ethanol binding)
GO:0046872 (metal ion binding)
GO:0051287 (NAD binding)
GO Biological Process GO:0001523 (retinoid metabolic process)
GO:0006066 (alcohol metabolic process)
GO:0006067 (ethanol metabolic process)
GO:0006069 (ethanol oxidation)
GO:0006081 (cellular aldehyde metabolic process)
GO:0042572 (retinol metabolic process)
GO:0046164 (alcohol catabolic process)
GO:0055114 (oxidation-reduction process)
GO:1901661 (quinone metabolic process)
Wikipedia ADH4

Target Cross References - Protein

Human Protein Atlas ENSG00000198099
IntAct P08319
Open Targets ENSG00000198099
PharmGKB PA24573
Reactome R-HSA-5365859 (RA biosynthesis pathway.)
R-HSA-71384 (Ethanol oxidation.)
UniProt A8K470 B4DIE7 C9J4A9 P08319 Q8TCD7

Target Cross References - Domain

InterPro IPR002328 (ADH_Zn_CS.)
IPR011032 (GroES-like.)
IPR013149 (ADH_C.)
IPR013154 (ADH_N.)
IPR016040 (NAD(P)-bd_dom.)
IPR020843 (PKS_ER.)
IPR028632 (Zinc_ADH_II.)
Pfam PF00107 (ADH_zinc_N)
PF08240 (ADH_N)

Target Cross References - Structure

PDBe 3COS
CREDO 3COS
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