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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL298
Preferred Name Cholecystokinin B receptor
Synonyms CCK-B receptor | CCK-BR | CCK2-R | CCKBR | CCKRB | Cholecystokinin-2 receptor | Gastrin/cholecystokinin type B receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > cholecystokinin receptor

Target Components

Component Description Relationship Accession
Gastrin/cholecystokinin type B receptor SINGLE PROTEIN P32239

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095185 Cholecystokinin receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL324547 NETAZEPIDE Cholecystokinin B receptor antagonist 2 PubMed
CHEMBL1256717 ITRIGLUMIDE Cholecystokinin B receptor antagonist 2 Other PubMed
CHEMBL2062154 CI-988 Cholecystokinin B receptor antagonist 1 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000110148
Ensembl ENSG00000110148
GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004951 (cholecystokinin receptor activity)
GO:0005515 (protein binding)
GO:0015054 (gastrin receptor activity)
GO:0017046 (peptide hormone binding)
GO:0031741 (type B gastrin/cholecystokinin receptor binding)
GO:0046935 (1-phosphatidylinositol-3-kinase regulator activity)
GO Biological Process GO:0001696 (gastric acid secretion)
GO:0007165 (signal transduction)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0008283 (cell proliferation)
GO:0008284 (positive regulation of cell proliferation)
GO:0038188 (cholecystokinin signaling pathway)
GO:0043551 (regulation of phosphatidylinositol 3-kinase activity)
GO:0048565 (digestive tract development)
GO:0048732 (gland development)
Wikipedia Cholecystokinin_B_receptor

Target Cross References - Protein

canSAR P32239
Human Protein Atlas ENSG00000110148
IntAct P32239
Guide to Pharmacology 77
Open Targets ENSG00000110148
PharmGKB PA26143
Pharos P32239 (Tclin)
Reactome R-HSA-375276 (Peptide ligand-binding receptors.)
R-HSA-416476 (G alpha (q) signalling events.)
R-HSA-881907 (Gastrin-CREB signalling pathway via PKC and MAPK.)
UniProt A8K7P9 O75824 P32239 Q16144 Q92492 Q96LC6 Q9NYK7 Q9UBV1

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000314 (Gastrin_rcpt.)
IPR009126 (Cholcskin_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)